...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Medical Virology >Virological and clinical aspects of HBV-HCV coinfection in HIV positive patients.
【24h】

Virological and clinical aspects of HBV-HCV coinfection in HIV positive patients.

机译：HIV阳性患者中HBV-HCV合并感染的病毒学和临床方面。

获取原文
获取原文并翻译 | 示例
   

获取外文期刊封面封底 >>

       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

In a long-term follow-up study the clinical and virological presentation of HBV/HCV coinfection in anti-HIV positive patients was evaluated. Plasma HBV-DNA, HCV-RNA, and HIV-RNA were determined by PCR in 5 HBsAg/anti-HCV/anti-HIV positive patients, in 4 HBsAg/anti-HIV positive patients and in 82 anti-HCV/anti-HIV positive patients first observed at a Unit of Infectious Diseases in Naples (Italy) from 1990 to 2000 (follow up 6-16 years). All five hepatitis B and C coinfected patients showed reciprocal inhibition of viral replication on admission and during the follow up. At the end of the follow up a clearance of HBsAg from serum was observed in four patients and a clearance of anti-HCV in one of them. In two patients after clearance of HBsAg, evidence of occult HBV infection was observed, at times associated with a hepatic flare. None of the four patients with HIV/HBV coinfection lost HBsAg and none of the 82 with HIV/HCV coinfection lost anti-HCV during the follow up. In anti-HIV positive patients HBV/HCV coinfection is characterized by reciprocal inhibition of viral replication, more evident in HBV expression in plasma and at times by progression to occult HBV infection.
机译：在一项长期随访研究中，评估了抗HIV阳性患者中HBV / HCV合并感染的临床和病毒学表现。通过PCR测定5例HBsAg /抗HCV /抗HIV阳性患者，4例HBsAg /抗HIV阳性患者和82例抗HCV /抗HIV的血浆HBV-DNA，HCV-RNA和HIV-RNA从1990年至2000年在意大利那不勒斯传染病科首次观察到阳性患者（随访6至16岁）。所有五名乙型和丙型肝炎合并感染的患者在入院时和随访期间均显示出病毒复制的相互抑制。随访结束时，在四名患者中观察到HBsAg从血清中清除，其中一名患者清除了抗HCV。在清除HBsAg后的两名患者中，观察到隐匿性HBV感染的证据，有时伴有肝耀斑。在随访期间，四名HIV / HBV合并感染的患者均未丢失HBsAg，而82名HIV / HCV合并感染的患者均未丢失抗HCV。在抗HIV阳性患者中，HBV / HCV合并感染的特征是相互抑制病毒复制，这种现象在血浆HBV表达中更为明显，有时甚至会发展为隐匿性HBV感染。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号