...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Medical Virology >Detection of varicella-zoster virus DNA in 414 human trigeminal ganglia from cadavers by the polymerase chain reaction: a comparison of the detection rate of varicella-zoster virus and herpes simplex virus type 1.
【24h】

Detection of varicella-zoster virus DNA in 414 human trigeminal ganglia from cadavers by the polymerase chain reaction: a comparison of the detection rate of varicella-zoster virus and herpes simplex virus type 1.

机译：聚合酶链反应检测尸体中414人三叉神经节中的水痘带状疱疹病毒DNA：水痘带状疱疹病毒和1型单纯疱疹病毒检出率的比较。

获取原文
获取原文并翻译 | 示例
   

获取外文期刊封面封底 >>

       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Investigation of varicella-zoster virus (VZV) is important epidemiologically, and determination of its prevalence rate in human trigeminal ganglia is important to provide surveillance data. To date, studies on VZV detection in trigeminal ganglia have used specimens obtained from a relatively limited number of cadavers. This study attempted to detect VZV DNA as well as Herpes simplex virus type 1 (HSV-1) DNA by the polymerase chain reaction (PCR) from 414 samples of trigeminal ganglia obtained from 207 cadavers selected at random. The detection rate was examined to determine whether there were significant differences in the positive rate between the left and right trigeminal ganglia, males and females, and among age groups. A relationship was found between the positive rates for VZV and HSV-1. VZV DNA was detected in 391 of the trigeminal ganglia (94.4%) and 201 of the cadavers (97.1%) in 121/124 males and 80/83 females. HSV-1 DNA was detected in 251 of the samples (60.6%) and 134 of the cadavers (64.7%) in 72/124 males and 62/83 females. There was no significant difference for either virus in the detection rates between the left and right trigeminal ganglia and males and females. Age and positivity for HSV-1, but not VZV, showed a significant relationship. All 134 cadavers positive for HSV-1 were also positive for VZV. VZV and HSV-1 become latent in bilateral trigeminal ganglia, and are not affected by gender. The prevalence of HSV-1 was greater in advanced age, and the HSV-1-positive rate was correlated with the VZV-positive rate.
机译：水痘带状疱疹病毒（VZV）的研究在流行病学上很重要，确定其在人三叉神经节中的流行率对提供监测数据也很重要。迄今为止，有关三叉神经节中VZV检测的研究已使用从相对有限的尸体中获得的标本。这项研究试图通过聚合酶链反应（PCR）从随机选择的207具尸体中获得的414个三叉神经节样本中检测VZV DNA和1型单纯疱疹病毒（HSV-1）DNA。检查检出率以确定左，右三叉神经节，男性和女性以及年龄组之间的阳性率是否存在显着差异。发现VZV和HSV-1的阳性率之间存在关系。在121/124位男性和80/83位女性中，在三叉神经节的391位（94.4％）和201位尸体（97.1％）中检测到VZV DNA。在72/124名男性和62/83名女性中，在251个样本（60.6％）和134个尸体（64.7％）中检测到HSV-1 DNA。左右三叉神经节与男性和女性之间，两种病毒的检出率均无显着差异。 HSV-1（而非VZV）的年龄和阳性表现出显着的相关性。 HSV-1阳性的所有134具尸体也均为VZV阳性。 VZV和HSV-1在双边三叉神经节中潜伏，不受性别影响。晚期HSV-1的患病率较高，且HSV-1阳性率与VZV阳性率相关。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号