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首页> 外文期刊>Journal of Medical Virology >Molecular characterization of BK polyomavirus subtypes in renal transplant recipients in Brazil.
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Molecular characterization of BK polyomavirus subtypes in renal transplant recipients in Brazil.

机译：巴西肾移植受者中BK多瘤病毒亚型的分子特征。

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摘要

BK polyomavirus (BKV) is highly prevalent in the world population. Different reports indicate that BKV subtypes and subgroups present an uneven geographical distribution which might be correlated with human migration. However, there is a lack of data on the BKV subtype distribution in the South American population. The occurrence of BKV subtypes and subgroups detected in 51 kidney transplant recipients in Rio de Janeiro, Brazil is described. According to genetic studies, the population in this region descends mainly from European or African immigrants, with a relatively low genetic background from the Amerindians. By sequencing the VP1 region of BKV, subgroups Ib1 and Ia of subtype I were found in 34 (67%) and 15 (29%), respectively, of samples, while subtype II was present in 2 (4%) of the samples. Subtypes III and IV were not detected. Phylogenetic analysis indicated similarities between Brazilian BKV subgroup Ia and East African lineages; and subgroup Ib-1 with Asian and North American lineages, while subtype II samples were similar to sequences from Japan and the UK. This is the first report that describes distribution of BKV subtypes in South America. The high prevalence of BKV subgroup Ia probably reflects the high proportion of African descendants in this population. On the other hand, the predominance of subgroup Ib-1 and the absence of Ib-2 in an area with a high proportion of European ancestry was unexpected. Further studies in South American populations are needed to provide a better understanding of the epidemiology of BKV in this region.
机译：BK多瘤病毒（BKV）在世界人口中非常流行。不同的报告表明，BKV亚型和亚组的地理分布不均，可能与人类迁徙有关。但是，缺乏有关南美人群中BKV亚型分布的数据。描述了在巴西里约热内卢的51名肾脏移植受者中检测到的BKV亚型和亚组的发生。根据遗传研究，该地区的人口主要来自欧洲或非洲移民，而来自美洲印第安人的遗传背景相对较低。通过对BKV的VP1区域进行测序，分别在34个样本（67％）和15个样本（29％）中发现了亚型I的亚群Ib1和Ia，而在2个样本中（4％）存在了亚型II。未检测到亚型III和IV。系统发育分析表明，巴西BKV Ia亚群与东非血统相似。亚洲和北美血统的亚群Ib-1，而亚型II的样本与日本和英国的序列相似。这是描述南美洲BKV亚型分布的第一份报告。 BKV Ia亚型的高患病率可能反映了非洲后裔在这一人群中的比例很高。另一方面，在欧洲血统比例高的地区，Ib-1亚组占优势，而Ib-2缺失。需要对南美人群进行进一步研究，以更好地了解该地区的BKV流行病学。

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