...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Medical Virology >Two years outcome of women infected with high risk HPV having normal colposcopy following low-grade or equivocal cytological abnormalities: Are HPV16 and 18 viral load clinically useful predictive markers?
【24h】

Two years outcome of women infected with high risk HPV having normal colposcopy following low-grade or equivocal cytological abnormalities: Are HPV16 and 18 viral load clinically useful predictive markers?

机译：低度或模棱两可的细胞学异常后阴道镜检查正常的高危HPV感染妇女的两年结局：HPV16和18病毒载量是否在临床上有用的预测指标？

获取原文
获取原文并翻译 | 示例
   

获取外文期刊封面封底 >>

       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Management of patients infected with high-risk HPV (hrHPV) despite normal colposcopy following abnormal cytology remains a clinical challenge. The aim of this study was to evaluate if, in that specific population, initial HPV 16 and HPV 18 viral loads are predictive of infection clearance over a 24-month follow-up. A total of 67 women infected with hrHPV having normal colposcopy following equivocal or low-grade cytological abnormalities were recruited and attended regular follow-ups based on repeat colposcopies and HPV testing. HPV16 and HPV18 infection were diagnosed in 36 (53.7%) and 7 (10.4%) cases, respectively. Viral load was quantified using the quantitative duplex real-time PCR method. Although this was not observed for HPV 18, initial HPV 16 viral load was highly associated to HPV 16 infection outcome (receiver operating characteristic curve analysis, area under curve: 0.90). Thus, women who had cleared their HPV 16 infection had significantly lower median initial HPV 16 viral load than those with persistent HPV 16 infection: 1.5×10 3 copies per million cells (CPMC) versus 3.8×10 6 CPMC, respectively (P=0.006). The best prediction of HPV 16 clearance was obtained with an initial HPV 16 viral load of 7.5×10 4 CPMC: 86.7% specificity and 85.7% sensitivity. Finally, six patients were diagnosed with grade 2 or 3 cervical or vaginal intraepithelial neoplasia. Although all had a persistent hrHPV infection, neither HPV 16 nor 18 viral loads were found to be predictive of the risk of cervical or vaginal intraepithelial neoplasia. HPV16 viral load quantitation could represent a clinically useful marker in that very specific population.
机译：尽管细胞学检查异常后阴道镜检查正常，但感染高危HPV（hrHPV）的患者的管理仍是一项临床挑战。这项研究的目的是评估在该特定人群中，最初的HPV 16和HPV 18病毒载量是否可预测24个月随访期间的感染清除率。总共招募了67名因高清晰度或低度细胞学异常而阴道镜检查正常的hrHPV感染妇女，并根据重复的阴道镜检查和HPV测试定期进行随访。 HPV16和HPV18感染分别诊断为36（53.7％）和7（10.4％）例。使用定量双工实时PCR方法定量病毒载量。尽管未对HPV 18观察到此情况，但初始HPV 16病毒载量与HPV 16感染结果高度相关（受试者工作特征曲线分析，曲线下面积：0.90）。因此，已清除其HPV 16感染的女性的初始HPV 16病毒中位数明显低于持续感染HPV 16的女性：每百万细胞1.5×10 3个拷贝（CPMC）与3.8×10 6 CPMC相比（P = 0.006） ）。 HPV 16清除率的最佳预测是在初始HPV 16病毒载量小于7.5×10 4 CPMC时进行的：特异性为86.7％，敏感性为85.7％。最后，六名患者被诊断出患有2或3级宫颈或阴道上皮内瘤变。尽管所有患者均具有持续的hrHPV感染，但未发现HPV 16和18的病毒载量可预测宫颈或阴道上皮内瘤变的风险。 HPV16病毒载量定量可以代表该特定人群中的临床有用标志物。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号