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首页> 外文期刊>Journal of Medical Virology >Clinical and virological characteristics of hepatitis B or C virus co-infection with HIV in Indonesian patients
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Clinical and virological characteristics of hepatitis B or C virus co-infection with HIV in Indonesian patients

机译：印度尼西亚患者乙型或丙型肝炎病毒与HIV合并感染的临床和病毒学特征

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Hepatitis virus-related liver disease increases substantially the mortality rate of patients with HIV on highly active antiretroviral therapy (HAART). Therefore, early diagnosis of hepatitis B virus (HBV) and hepatitis C virus (HCV) is important. However, the prevalence of HBV and HCV infection in Indonesian patients infected with HIV is unknown. Therefore, this study examined the molecular and clinical characteristics of HBV and HCV in 126 patients infected with HIV, mostly on HAART, at Dr. Sardjito Hospital, Yogyakarta, Indonesia. The rates of triple infection, HIV/HCV co-infection, HIV/HBV co-infection, and mono-infection were 4.8%, 34.1%, 3.2%, and 57.9%, respectively. Seven HCV genotypes were detected, with genotypes 1a, 1b, 1c, 3a, 3k, 4a, and 6n found in 23 (52%), 1 (2%), 4 (9%), 5 (11%), 7 (16%), 3 (6%), and 1 (2%) patients, respectively, indicating multiple modes of transmission. HBV-DNA was detected in 2/10 patients with hepatitis B surface antigen; both patients were HAART naive. Univariate analysis revealed that male sex, higher education level, injection drug use, sexual contact, alanine aminotransferase ≥40IU/L, and aspartate aminotransferase-to-platelet ratio index>0.5 were associated with HCV co-infection. In multivariate analysis, injection drug use (OR: 26.52; 95% CI: 3.52-199.54) and alanine aminotransferase ≥40IU/L (OR: 6.36; 95% CI: 1.23-32.89) were independently associated with HCV co-infection. HCV co-infection was common among Indonesian patients infected with HIV, particularly among injecting drug users, and was a risk factor for disease progression of HIV.
机译：肝炎病毒相关的肝病大大提高了接受高活性抗逆转录病毒疗法（HAART）的HIV患者的死亡率。因此，早期诊断乙型肝炎病毒（HBV）和丙型肝炎病毒（HCV）很重要。然而，印度尼西亚感染艾滋病毒的患者中HBV和HCV感染的患病率尚不清楚。因此，这项研究在印度尼西亚日惹的萨吉托医生医院检查了126例感染HIV的患者的HBV和HCV的分子和临床特征，其中大部分是通过HAART进行的。三重感染，HIV / HCV合并感染，HIV / HBV合并感染和单一感染的发生率分别为4.8％，34.1％，3.2％和57.9％。共检测到7种HCV基因型，分别在23（52％），1（2％），4（9％），5（11％），7（9）中发现了基因型1a，1b，1c，3a，3k，4a和6n。 16％），3（6％）和1（2％）的患者，表明多种传播方式。在2/10例乙型肝炎表面抗原患者中检测到HBV-DNA;两名患者均为HAART天真。单因素分析显示，男性，高学历，注射毒品，性接触，丙氨酸氨基转移酶≥40IU/ L，天冬氨酸氨基转移酶与血小板之比指数> 0.5与HCV合并感染有关。在多变量分析中，注射毒品的使用（OR：26.52; 95％CI：3.52-199.54）和丙氨酸转氨酶≥40IU/ L（OR：6.36; 95％CI：1.23-32.89）与HCV合并感染独立相关。 HCV合并感染在印度尼西亚感染HIV的患者中很常见，尤其是在注射吸毒者中，并且是HIV疾病发展的危险因素。

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