Synthesis of new cyclitol compounds that influence the activity of phosphatidylinositol 4-kinase isoform, PI4K230.

Pelyvas IF; Toth ZG; Vereb G; Balla A; Kovacs E; Gorzsas A; Sztaricskai F; Gergely P

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Synthesis of new cyclitol compounds that influence the activity of phosphatidylinositol 4-kinase isoform, PI4K230.

机译：合成影响磷脂酰肌醇4-激酶同工型PI4K230的新环糖醇化合物。

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The synthesis, chemical derivatization, and investigation of the inhibitory properties of novel cyclitol derivatives on the phosphatidylinositol 4-kinase enzymes PI4K55 and PI4K230 involved in the phosphatidylinositol cycle are reported. Some of the prepared cyclitol derivatives (i.e. 9, 11, 12, and 14) proved to be very powerful and specific irreversible inhibitors of PI4K230 at or below a concentration of 1 mM.

机译：据报道，新型环糖醇衍生物的合成，化学衍生化以及对磷脂酰肌醇循环中涉及的磷脂酰肌醇4-激酶PI4K55和PI4K230的抑制特性的研究。某些制备的环糖醇衍生物（即9、11、12和14）证明是非常有效的，且浓度为1 mM或以下的PI4K230的特定不可逆抑制剂。

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《Journal of Medicinal Chemistry》 |2001年第4期|共6页
作者
Pelyvas IF; Toth ZG; Vereb G; Balla A; Kovacs E; Gorzsas A; Sztaricskai F; Gergely P;
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正文语种 eng
中图分类药学;
关键词
Cyclohexanones; Enzyme Inhibitors; Phosphotransferases Alcohol Group Acceptor antagonists and inhibitors; 环己酮类; 酶抑制剂; 糖醇类;

机译：Cyclohexanones;Enzyme Inhibitors;Phosphotransferases Alcohol Group Acceptor antagonists and inhibitors;环己酮类;酶抑制剂;糖醇类;

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1. Synthesis of new cyclitol compounds that influence the activity of phosphatidylinositol 4-kinase isoform, PI4K230. [J] . Pelyvas IF, Toth ZG, Vereb G, Journal of Medicinal Chemistry . 2001,第4期

机译：合成影响磷脂酰肌醇4-激酶同工型PI4K230的新环糖醇化合物。
2. Evolutionarily conserved structural changes in phosphatidylinositol 5-phosphate 4-kinase (PI5P4K) isoforms are responsible for differences in enzyme activity and localization. [J] . Clarke J. H., Irvine R. F. The Biochemical Journal . 2013,第Pta1期

机译：磷脂酰肌醇5-磷酸4-激酶（PI5P4K）同工型中进化上保守的结构变化是造成酶活性和定位差异的原因。
3. Synthesis and structure-activity relationship of ribofuranosyl echiguanine analogs as inhibitors of phosphatidylinositol 4-kinase [J] . Saito Y., Umezawa K., Kato K. Tetrahedron . 1998,第17期

机译：核呋喃糖基棘鸟嘌呤类似物作为磷脂酰肌醇4-激酶抑制剂的合成及其构效关系
4. An In Silico Approach for Targeting Plasmodium Phosphatidylinositol 4-Kinase to Eradicate Malaria [C] . Kamal Kumar Chaudhary, Sarvesh Kumar Gupta, Nidhi Mishra International Conference on Advanced Computing and Communication Technologies . 2016

机译：一种靶向磷脂酰肌醇4-激酶以根除疟疾的三种方法
5. 1. Selective facilitated transport of biological compounds through a phospholipid bilayer using boronic acid complexation. 2. Influence of eluent anions in boronate affinity chromatography. 3. Photoregulation of enzyme activity: Synthesis and study of pho [D] . Westmark, Pamela Rae. 1996

机译：1.使用硼酸络合选择性促进生物化合物通过磷脂双层的运输。 2.洗脱液阴离子在硼酸酯亲和色谱中的影响。 3.酶活性的光调节：磷酸的合成与研究
6. Evolutionarily conserved structural changes in phosphatidylinositol 5-phosphate 4-kinase (PI5P4K) isoforms are responsible for differences in enzyme activity and localization [O] . Jonathan H. Clarke, Robin F. Irvine -1

机译：磷脂酰肌醇5-磷酸4-激酶（PI5P4K）亚型的进化保守结构变化是酶活性和定位差异的原因
7. Phosphatidylinositol 4-Kinase III Beta Is a Target of Enviroxime-Like Compounds for Antipoliovirus Activity▿ † [O] . Arita, Minetaro, Kojima, Hirotatsu, Nagano, Tetsuo, 2010

机译：磷脂酰肌醇4-激酶III Beta是抗脊髓灰质炎病毒活性的类Enviroxime类化合物的靶标

Synthesis of new cyclitol compounds that influence the activity of phosphatidylinositol 4-kinase isoform, PI4K230.

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