Synthesis of 3,4-Dihydro-2H-1,2,4-benzo- thiadiazine 1,1-Dioxide Derivatives as Potential Allosteric Modulators of AMPA/Kainate Receptors.

Braghiroli D; Puia G; Cannazza G; Tait A; Parenti C; Losi G; Baraldi M

首页> 外文期刊>Journal of Medicinal Chemistry >Synthesis of 3,4-Dihydro-2H-1,2,4-benzo- thiadiazine 1,1-Dioxide Derivatives as Potential Allosteric Modulators of AMPA/Kainate Receptors.

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Synthesis of 3,4-Dihydro-2H-1,2,4-benzo- thiadiazine 1,1-Dioxide Derivatives as Potential Allosteric Modulators of AMPA/Kainate Receptors.

机译：合成3,4-二氢-2H-1,2,4-苯并噻二嗪1,1-二氧化物衍生物作为AMPA / Kainate受体的潜在变构调节剂。

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A series of 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide derivatives were synthesized and evaluated for their activity as allosteric modulators of kainate-activated currents in primary cultures of cerebellar granule neurons. Substitution of different groups at the 3-position of the benzothiadiazine ring distinguished between positive and negative allosteric modulatory properties.

机译：合成了一系列的3,4-二氢-2H-1,2,4-苯并噻二嗪1,1-二氧化物衍生物，并评估了它们在小脑颗粒神经元原代培养物中作为红藻氨酸激活电流的变构调节剂的活性。苯并噻二嗪环的3位上的不同基团的取代区分了正和负变构调节特性。

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《Journal of Medicinal Chemistry》 |2002年第12期|共3页
作者
Braghiroli D; Puia G; Cannazza G; Tait A; Parenti C; Losi G; Baraldi M;
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正文语种 eng
中图分类药学;
关键词
Synthesis; Potential; Receptors; Kainic Acid; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; 受体; 红藻胺酸; α-氨基-3-羟基-5-甲基-4-异唑丙酸; 噻二嗪类;

机译：Synthesis;Potential;Receptors;Kainic Acid;alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid;受体;红藻胺酸;α-氨基-3-羟基-5-甲基-4-异唑丙酸;噻二嗪类;

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1. Synthesis of 3,4-Dihydro-2H-1,2,4-benzo- thiadiazine 1,1-Dioxide Derivatives as Potential Allosteric Modulators of AMPA/Kainate Receptors. [J] . Braghiroli D, Puia G, Cannazza G, Journal of Medicinal Chemistry . 2002,第12期

机译：合成3,4-二氢-2H-1,2,4-苯并噻二嗪1,1-二氧化物衍生物作为AMPA / Kainate受体的潜在变构调节剂。
2. 7-Phenoxy-Substituted 3,4-Dihydro-2H-1,2,4-benzothiadiazine 1,1-Dioxides as Positive Allosteric Modulators of α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors with Nanomolar Potency [J] . Eric Goffin, Thomas Drapier, Anja Probst Larsen, Journal of Medicinal Chemistry . 2018,第1期

机译：将7-苯氧基取代的3,4-二氢-2 -1-1,2,4-苯并噻嗪二嗪1,1-二氧化氧化物作为α-氨基-3-羟基-5-甲基的正变形调节剂具有纳摩尔效力的4-异恶唑丙酸（AMPA）受体
3. Application of 3-Methylthiopyrido[4,3-e]-1,4,2-dithiazine 1,1-Dioxide to the Synthesis of Novel Series of 4H-Pyrido[4,3-e]-1,2,4-thiadiazine Derivatives with Potential Biological Activity [J] . Brzozowski Z, Slawinski J, Kedzia A, Journal of Heterocyclic Chemistry: The International Journal of Heterocyclic Chemistry . 2009,第6期

机译：3-甲硫基吡啶并[4,3-e] -1,4,2-二噻嗪1,1-二氧化物在新型4H-吡啶并[4,3-e] -1,2,4-噻二嗪的合成中的应用具有潜在生物活性的衍生物
4. SYNTHESIS OF SOME 7H-s-TRIAZOLO3,4-b-1,3,4-THIADIAZINE DERIVATIVES [C] . Heng-Shan Dong International symposium for Chinese organic chemists . 2000

机译：一些7H-S-Tri唑的合成3,4-B -1,3,4-噻二嗪衍生物
5. A functional study of AMPA and kainate receptors. [D] . Han, Yan. 2011

机译：AMPA和海藻酸酯受体的功能研究。
6. Synthesis of Novel Pyrido43-e124triazino32-c124thiadiazine 66-dioxide Derivatives with Potential Anticancer Activity [O] . Jarosław Sławiński, Aleksandra Grzonek, Beata Żołnowska, 2016

机译：具有潜在抗癌活性的新型吡啶并43-e 124三嗪32-c 124噻二嗪66-二氧化物衍生物的合成
7. Synthesis and Evaluation of Novel 2H-Benzoe-1,2,4thiadiazine 1,1-Dioxide Derivatives as PI3Kδ Inhibitors [O] . 2019

机译：新型2H-苯并E - 1,2,4噻二嗪1,1-二氧化氧化物衍生物作为PI3Kδ抑制剂的合成与评价
8. Synthesis and Crystal Structure of (Mo2FePt(mu-sigma, sigma', sigma'': eta(5)-CC5H4)2(CO)4(HB(Pz)3)2) (HB(pz)3 = Hydrotris(pyrazol-1,1-YL)Norate): A Complex Derived from a 1,1'Ferrocene Derivative with C (Triple bond) Mo(CO)2(HB(pz)3) Substituents. [R] . Davies, S. J., Hill, A. F., Pilotti, M. U., 1989

机译：（mo2Fept（μ-sigma，sigma'，sigma''：eta（5）-CC5H4）2（CO）4（HB（pz）3）2）（HB（pz）3 = Hydrotris（吡唑）的合成和晶体结构-1,1-YL）Norate）：衍生自具有C（三键）mo（CO）2（HB（pz）3）取代基的1,1'-二茂烯衍生物的络合物。

Synthesis of 3,4-Dihydro-2H-1,2,4-benzo- thiadiazine 1,1-Dioxide Derivatives as Potential Allosteric Modulators of AMPA/Kainate Receptors.

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