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首页> 外文期刊>Journal of Molecular and Cellular Cardiology >The salt of the earth: Focus on Na+ regulation in the cardiac myocyte
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The salt of the earth: Focus on Na+ regulation in the cardiac myocyte

机译：地球的盐：专注于心肌细胞中的Na +调节

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Although biblical in origin, the phrase "The salt of the earth" first found its way into common English prose in Geoffrey Chaucer's Summoner's Tale in 1386 and is used to denote utmost worthiness of an individual. In addition to his literary talents, Chaucer was well versed in science and his Treatise on the Astrolabe, often cited as the first example of technical writing in the English language, begins with the address to his son "I perceive well by certain evidences thine ability to learn sciences touching numbers and proportions". The cationic constituent of common salt, Na+, justifiably maligned as a dietary risk factor when consumed in excess, is critical for normal cell function and the maintenance of its "numbers and proportions" (i.e. homeostasis), and the consequences of disruptions therein, form the focus of this Special Issue. In order to achieve homeostasis, mammalian cells expend a large amount of metabolic energy, through the Na+/K+ ATPase or "Na+ pump", to maintain the intracellular Na+ concentration ([Na+]i) at an almost 15-fold lower level than the extracellular Na+ concentration (in the absence of such active Na+ extrusion, [Na+]j would arrive at equilibrium in a cardiac myocyte at -80 mV at a staggering 3.3 mol/L!). Having invested heavily in establishing a large electrochemical Na+ gradient, the cell exploits this to generate electrical impulses in excitable tissues, such as nerve and muscle, and to power the energetically unfavourable transport of other ions (Ca2+, H+, HCOJ) and metabolites (e.g. amino acids, glucose) across the cell membrane.
机译：尽管起源于圣经，但“地球的盐”一词在1386年的杰弗里·乔uc的《召唤师的故事》中首次在普通英语散文中出现，用来表示个人的最大价值。除了文学才能外，乔uc还精通科学，他的《星盘论》（通常被称为英语技术写作的第一个例子）首先是对儿子的讲话：“我对某些证据的理解很好学习触及数字和比例的科学”。过量食用时，钠盐的阳离子成分有正当的饮食风险因素，它对正常细胞功能及其维持其“数量和比例”（即体内稳态）及其破坏的后果至关重要。本期特刊的重点。为了达到体内平衡，哺乳动物细胞通过Na + / K + ATPase或“ Na +泵”消耗大量的代谢能，以维持细胞内Na +浓度（[Na +] i）低于其15倍。细胞外Na +浓度（在没有这种活性Na +挤出的情况下，[Na +] j在-80 mV处达到惊人的3.3 mol / L时会在心肌细胞中达到平衡）。在建立大型电化学Na +梯度上进行了大量投资后，该细胞利用它在兴奋性组织（如神经和肌肉）中产生电脉冲，并为其他离子（Ca2 +，H +，HCOJ）和代谢物（例如，氨基酸，葡萄糖）穿过细胞膜。

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