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首页> 外文期刊>Journal of nanoparticle research: An interdisciplinary forum for nanoscale science and technology >Comparative in vitro cytotoxicity assessment of some manufactured nanoparticulate materials characterized by transmission electron microscopy
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Comparative in vitro cytotoxicity assessment of some manufactured nanoparticulate materials characterized by transmission electron microscopy

机译：透射电镜表征某些人造纳米颗粒材料的体外细胞毒性比较评估

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摘要

A range of manufactured nanoparticulate materials, including Ag, TiO2, Fe2O3, Al2O3, ZrO2, Si3N4, and a range of carbonaceous nanoparticulate materials: single-wall and multi-wall carbon nanotube aggregates and aggregated nanoparticles of black carbon, as well as commercial (mineral grade) chrysotile asbestos nanotube aggregates, have been rigorously characterized by transmission electron microscopy. These nanoparticulate materials ranged in primary particle sizes from roughly 3 to 150 nm (except for the nanotube materials with lengths in excess of 15 mu m). Aggregate sizes ranged from 25 nm to 20 mu m. Comparative cytotoxicological assessment of these nanomaterials was performed utilizing a murine (lung) macrophage cell line. Considering the chrysotile asbestos to be a positive control, and assigning it a relative cytotoxicity index of unity (1.0), relative cytotoxicity indexes were observed as follows at concentrations of 5 mu g/ml: 1.6 and similar to 0.4 for Ag and TiO2, respectively; 0.7-0.9 for the Fe2O3, Al2O3 and ZrO2, 0.4 for the Si3N4, 0.8 for the black carbon, and 0.9 to 1.1 for the carbon nanotube aggregate samples. Observations of a cytotoxic response, nearly identical to that for chrysotile asbestos, for multi-wall carbon nanotube aggregates which very closely resemble anthropogenic multi-wall carbon nanotubes in the environment, raise some concern for potential health effects, especially for long-term exposure.
机译：一系列制造的纳米颗粒材料，包括Ag，TiO2，Fe2O3，Al2O3，ZrO2，Si3N4，以及一系列碳质纳米颗粒材料：单壁和多壁碳纳米管聚集体以及黑碳的聚集纳米颗粒，以及商用（矿物级）温石棉石棉纳米管聚集体，已通过透射电子显微镜进行了严格表征。这些纳米颗粒材料的初级粒径范围约为3至150 nm（长度超过15微米的纳米管材料除外）。骨料尺寸范围为25 nm至20μm。利用鼠（肺）巨噬细胞系进行了这些纳米材料的比较细胞毒理学评估。将温石棉作为阳性对照，并将其指定为1的相对细胞毒性指数（1.0），在5μg / ml的浓度下观察到的相对细胞毒性指数如下：Ag和TiO2分别为1.6和0.4左右; Fe2O3，Al2O3和ZrO2为0.7-0.9，Si3N4为0.4，黑碳为0.8，碳纳米管聚集体样品为0.9至1.1。对于多壁碳纳米管聚集体（与环境中的人为多壁碳纳米管非常相似）的细胞毒性反应的观察结果与温石棉的细胞毒性反应几乎相同，这引起了人们对潜在健康影响（尤其是长期暴露）的担忧。

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