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首页> 外文期刊>Journal of nanoparticle research: An interdisciplinary forum for nanoscale science and technology >Chemical approach to solvent removal during nanoencapsulation: its application to preparation of PLGA nanoparticles with non-halogenated solvent
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Chemical approach to solvent removal during nanoencapsulation: its application to preparation of PLGA nanoparticles with non-halogenated solvent

机译：纳米封装过程中化学去除溶剂的方法：其在使用非卤代溶剂制备PLGA纳米颗粒中的应用

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The objective of this study was to develop a new oil-in-water emulsion-based nanoencapsulation method for the preparation of PLGA nanoparticles using a non-halogenated solvent. PLGA (60-150 mg) was dissolved in 3 ml of methyl propionate, which was vortexed with 4 ml of a 0.5-4 % polyvinyl alcohol solution. This premix was sonicated for 2 min, added into 30 ml of the aqueous polyvinyl alcohol solution, and reacted with 3 ml of 10 N NaOH. Solvent removal was achieved by the alkaline hydrolysis of methyl propionate dissolved in an aqueous phase into water-soluble methanol and sodium propionate. It was a simple but effective technique to quickly harden nanoemulsion droplets into nanoparticles. The appearing PLGA nanoparticles were recovered by ultracentrifugation and/or dialysis, lyophilized with trehalose, and redispersed by water. This nanoencapsulation technique permitted a control of their mean diameters over 151.7 +/- 3.8 to 440.2 +/- 22.2 nm at mild processing conditions. When the aqueous polyvinyl alcohol concentration was set at >= 1 %, nanoparticles showed uniform distributions with polydispersity indices below 0.1. There were no significant changes in their mean diameters and size distribution patterns before and after lyophilization. When mestranol was encapsulated into nanoparticles, the drug was completely nanoencapsulated: depending on experimental conditions, their encapsulation efficiencies were determined to be 99.4 +/- 7.2 to 105.8 +/- 6.3 %. This simple, facile nanoencapsulation technique might have versatile applications for the preparation of polymeric nanoparticulate dosage forms.
机译：这项研究的目的是开发一种新的基于水包油乳液的纳米囊化方法，用于使用非卤代溶剂制备PLGA纳米颗粒。将PLGA（60-150mg）溶解在3ml的丙酸甲酯中，将其与4ml的0.5-4％聚乙烯醇溶液涡旋。将该预混合物超声处理2分钟，添加到30 ml的聚乙烯醇水溶液中，并与3 ml的10 N NaOH反应。通过将溶于水相的丙酸甲酯碱水解为水溶性甲醇和丙酸钠来实现溶剂去除。这是一种将纳米乳剂液滴快速硬化成纳米颗粒的简单但有效的技术。通过超速离心和/或透析回收出现的PLGA纳米颗粒，用海藻糖冻干，然后用水再分散。这种纳米封装技术允许在温和的加工条件下将其平均直径控制在151.7 +/- 3.8至440.2 +/- 22.2 nm之间。当聚乙烯醇水溶液的浓度设置为≥1％时，纳米颗粒显示出均匀的分布，多分散指数低于0.1。在冻干之前和之后，它们的平均直径和大小分布模式没有显着变化。当将甲羟雌醇封装到纳米颗粒中时，药物被完全纳米封装：根据实验条件，确定其封装效率为99.4 +/- 7.2至105.8 +/- 6.3％。这种简单，便捷的纳米封装技术可能在制备聚合物纳米颗粒剂型方面具有广泛的应用。

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