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首页> 外文期刊>Biophysical Chemistry: An International Journal Devoted to the Physical Chemistry of Biological Phenomena >Interaction of alkaline-earth metal ions with calf thymus DNA. Volume and compressibility effects in diluted aqueous solutions.
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Interaction of alkaline-earth metal ions with calf thymus DNA. Volume and compressibility effects in diluted aqueous solutions.

机译：碱土金属离子与小牛胸腺DNA的相互作用。稀释水溶液的体积和可压缩性影响。

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摘要

The binding of Mg2+, Ca2+, Sr2+ and Ba2+ ions to calf thymus DNA in solutions has been investigated by ultrasonic and densimetric techniques. The obtained parameters, the apparent molar volume, phiV, and the apparent molar adiabatic compressibility, phiK(S), are very sensitive to hydration of investigated molecules. The interaction between the cations and DNA is accompanied by overlapping their hydration shells and consequently releasing the water molecules from hydration shells to bulk state. The change in the hydration is reflected in the measured parameters, phiV and phiK(S). The magnitude of these hydration changes is determined by the position of the cation relative to DNA atomic groups involved in the binding, and thus can characterize the structure of cation-DNA complexes. The values of the dehydration effects of the binding, deltaphiV and deltaphiK(S), correspond to two direct or higher number of indirect contacts between calf thymus DNA and the cations.
机译：已经通过超声和​​密度技术研究了溶液中Mg2 +，Ca2 +，Sr2 +和Ba2 +离子与小牛胸腺DNA的结合。获得的参数，表观摩尔体积phiV和表观摩尔绝热可压缩性phiK（S）对所研究分子的水合非常敏感。阳离子与DNA之间的相互作用伴随着它们的水合壳重叠，因此将水分子从水合壳释放到堆积状态。水合的变化反映在测得的参数phiV和phiK（S）中。这些水合变化的幅度由阳离子相对于结合中涉及的DNA原子基团的位置决定，因此可以表征阳离子-DNA络合物的结构。结合的脱水作用值deltaphiV和deltaphiK（S）对应于小牛胸腺DNA和阳离子之间的两个直接或更高数量的间接接触。

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