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Epilepsy in pregnancy

机译:妊娠癫痫病

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摘要

Over 25,000 epileptic women deliver viable pregnancies each year in the United States. Although medical management is the first line of treatment, many physiological changes associated with pregnancy can make optimal treatment challenging. Medication dosage is adjusted based on side effects and seizure frequency, with the goal being no seizures with the lowest medication dosage(s) and side-effect profile possible. Whenever possible, monotherapy is preferred. Many antiepileptic drugs have teratogenic potential, so preconceptional optimization of medication dosage(s) is recommended. Epilepsy has associated neurological comorbidities, the most common being migraines and sleep disorders.
机译:在美国,每年有超过25,000名癫痫妇女进行可行的怀孕。尽管医学管理是治疗的第一线,但与妊娠相关的许多生理变化可能使最佳治疗具有挑战性。根据副作用和癫痫发作频率调整用药剂量,目标是尽可能减少用药剂量和副作用的发作。只要有可能,首选单药治疗。许多抗癫痫药具有致畸性,因此建议在孕前优化用药剂量。癫痫病伴有神经系统合并症,最常见的是偏头痛和睡眠障碍。

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