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首页> 外文期刊>Journal of neural transmission >Abeta peptides as one of the crucial volume transmission signals in the trophic units and their interactions with homocysteine. Physiological implications and relevance for Alzheimer's disease.
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Abeta peptides as one of the crucial volume transmission signals in the trophic units and their interactions with homocysteine. Physiological implications and relevance for Alzheimer's disease.

机译：Abeta肽是营养单元中至关重要的体积传输信号之一，并且与高半胱氨酸相互作用。阿尔茨海默氏病的生理学意义和相关性。

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Amyloid peptides (Abeta) can operate as volume transmission (VT) signals since they are continuously released from cells of the central nervous system and diffuse in the extra-cellular space of the brain. They have both regulatory and trophic functions on cellular networks. In agreement with Abeta regulatory actions on glial-neuronal networks, the present paper reports new findings demonstrating that intrastriatal injections of Abeta peptides reduce striatal tyrosine hydroxylase, increase striatal GFAP immunoreactivities and lower pain threshold in experimental rats. Furthermore, it has been demonstrated that exogenous homocysteine (Hcy) binds Abeta(1-40) favouring its beta-sheet conformation both in vitro and in vivo and hence the formation of beta-fibrils and development of neurotoxicity. Thus, the hypothesis is discussed that Abeta peptides represent crucial VT-signals in the brain and their action is altered by dysmetabolic signals such as high Hcy extra-cellular levels, known to be an important risk factor for Alzheimer's disease.
机译：淀粉样蛋白肽（Abeta）可以作为体积传输（VT）信号，因为它们从中枢神经系统的细胞中连续释放并扩散到大脑的细胞外空间。它们在蜂窝网络上既具有调节功能又具有营养功能。与Abeta对神经胶质神经网络的调节作用相一致，本文报道了新发现，表明纹状体内注射Abeta肽可降低实验大鼠的纹状体酪氨酸羟化酶，增加纹状体GFAP免疫反应性并降低疼痛阈值。此外，已证明外源性同型半胱氨酸（Hcy）结合Abeta（1-40）有利于其在体内和体外的β-折叠构造，因此形成了β-原纤维和神经毒性。因此，讨论了以下假设：Abeta肽代表大脑中至关重要的VT信号，并且其运动被代谢异常信号（例如高Hcy细胞外水平）改变，已知这是阿尔茨海默氏病的重要危险因素。

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