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首页> 外文期刊>Clinical oncology >Epirubicin, cisplatin and protracted venous infusion 5-Fluorouracil chemotherapy for advanced salivary adenoid cystic carcinoma.
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Epirubicin, cisplatin and protracted venous infusion 5-Fluorouracil chemotherapy for advanced salivary adenoid cystic carcinoma.

机译：表柔比星，顺铂和持续静脉输注5-氟尿嘧啶化疗治疗晚期唾液腺腺样囊性癌。

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AIMS: Adenoid cystic carcinoma (ACC) is a rare tumour that usually arises in the salivary glands. Initial management is surgery often combined with adjuvant radiotherapy. Chemotherapy is reserved for treatment of symptomatic recurrence. We evaluated the combination of epirubicin, cisplatin and protracted venous infusion 5-fluorouracil (ECF) in the management of ACC. MATERIALS AND METHODS: Patients referred for treatment of advanced, symptomatic ACC were considered. The drugs given were epirubicin 50 mg/m(2) 3-weekly, cisplatin 60 mg/m(2) 3-weekly and protracted venous infusion 5-fluorouracil 200 mg/m(2)/day. RESULTS: Eight patients (median age 46 years) received a median of five cycles of chemotherapy. All patients had had previous surgery, seven had had previous radiotherapy and one had had previous chemotherapy. One patient showed a partial response (duration 34 months) and five showed stable disease (median duration 13.6 months [6.8-15.9+ months]). Median survival was 27 months (3.5-62.3 months). CONCLUSIONS: The activity of ECF in ACC of the head and neck seems to be similar to the combination of cisplatin and 5-fluorouracil and single-agent epirubicin.
机译：目的：腺样囊性癌（ACC）是一种罕见的肿瘤，通常发生在唾液腺中。初始管理是外科手术，通常与辅助放疗相结合。化学疗法保留用于症状复发的治疗。我们评估了表柔比星，顺铂和持续静脉输注5-氟尿嘧啶（ECF）在ACC治疗中的组合。材料与方法：考虑转诊为晚期症状性ACC的患者。给予的药物为每周3次表柔比星50 mg / m（2），每周3周的顺铂60 mg / m（2）和持续静脉输注5-氟尿嘧啶200 mg / m（2）/天。结果：八名患者（中位年龄46岁）接受了五个化疗周期的中位数。所有患者均曾接受过手术，其中7人接受过放疗，1人接受过化疗。一名患者表现出部分反应（持续时间34个月），五名表现出稳定的疾病（中位病程13.6个月[6.8-15.9 +个月]）。中位生存期为27个月（3.5-62.3个月）。结论：ECF在头颈部ACC中的活性似乎与顺铂和5-氟尿嘧啶以及单药表柔比星的组合相似。

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