Crystal structure of rat GTP cyclohydrolase I feedback regulatory protein, GFRP

Bader G; Schiffmann S; Herrmann A; Fischer M; Gutlich M; Auerbach G

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Crystal structure of rat GTP cyclohydrolase I feedback regulatory protein, GFRP

机译：大鼠GTP环水解酶I反馈调节蛋白GFRP的晶体结构

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Tetrahydrobiopterin, the cofactor required for hydroxylation of aromatic amino acids regulates its own synthesis in mammals through feedback inhibition of GTP cyclohydrolase I. This mechanism is mediated by a regulatory subunit called GTP cyclohydrolase I feedback regulatory protein (GFR-P). The 2.6 Angstrom resolution crystal structure of rat GFRP shows that the protein forms a pentamer. This indicates a model for the interaction of mammalian GTP cyclohydrolase I with its regulator, GFRP. Kinetic investigations of human GTP cyclohydrolase I in complex with rat and human GFRP showed similar regulatory effects of both GFRP proteins.

机译：四氢生物蝶呤是芳香族氨基酸羟化所需的辅助因子，通过反馈抑制GTP环水解酶I来调节哺乳动物自身的合成。该机制由称为GTP环水解酶I反馈调节蛋白（GFR-P）的调节亚基介导。大鼠GFRP的2.6埃分辨率晶体结构表明该蛋白质形成五聚体。这表明了哺乳动物GTP环水解酶I及其调节剂GFRP相互作用的模型。与大鼠和人GFRP复合的人GTP环水解酶I的动力学研究表明，两种GFRP蛋白具有相似的调节作用。

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《Journal of Molecular Biology》 |2001年第5期|共7页
作者
Bader G; Schiffmann S; Herrmann A; Fischer M; Gutlich M; Auerbach G;
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正文语种 eng
中图分类分子生物学;
关键词
Gtp cyclohydrolase i; Tetrahydrobiopterin; Biosynthesis; Regulation; Tetrahydrobiopterin; Biosynthesis; Mechanisms; Purification; Biopterin; Program; Cloning; Tool;

机译：Gtp环水解酶;四氢生物蝶呤;生物合成;调控;四氢生物蝶呤;生物合成;机理;纯化;生物蝶呤;程序;克隆;工具;

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1. Crystal structure of rat GTP cyclohydrolase I feedback regulatory protein, GFRP [J] . Bader G, Schiffmann S, Herrmann A, Journal of Molecular Biology . 2001,第5期

机译：大鼠GTP环水解酶I反馈调节蛋白GFRP的晶体结构
2. GTP cyclohydrolase I feedback regulatory protein-dependent and -independent inhibitors of GTP cyclohydrolase I [J] . Yoneyama T., Hatakeyama K., Wilson LM. Archives of Biochemistry and Biophysics . 2001,第1期

机译：GTP环水解酶I反馈GTP环水解酶I的调节蛋白依赖性和非依赖性抑制剂
3. Ligand binding to the inhibitory and stimulatory GTP cyclohydrolase I/GTP cyclohydrolase I feedback regulatory protein complexes. [J] . Yoneyama T, Hatakeyama K Protein Science: A Publication of the Protein Society . 2001,第4期

机译：配体与抑制性和刺激性GTP环水解酶I / GTP环水解酶I的结合可反馈调节蛋白复合物。
4. Mathematical modeling of the role of cooperativity between contractile and regulatory proteins in the mechano-calcium feedbacks in myocardium [C] . Computing in Cardiology Conference . 2015

机译：收缩蛋白与调节蛋白在心肌机械钙反馈中协同作用的数学模型
5. Regulation of tetrahydrobiopterin synthesis by GTP cyclohydrolase feedback regulatory protein. [D] . Kolinsky, Monica Ann. 2004

机译：GTP环水解酶反馈调节蛋白调节四氢生物蝶呤的合成。
6. Crystal structure of the stimulatory complex of GTP cyclohydrolase I and its feedback regulatory protein GFRP [O] . Nobuo Maita, Kengo Okada, Kazuyuki Hatakeyama, 2002

机译：GTP环水解酶I及其反馈调节蛋白GFRP的刺激复合物的晶体结构
7. Crystal structure of the stimulatory complex of GTP cyclohydrolase I and its feedback regulatory protein GFRP [O] . Maita, Nobuo, Okada, Kengo, Hatakeyama, Kazuyuki, 2002

机译：GTP环水解酶I及其反馈调节蛋白GFRP的刺激复合物的晶体结构
8. Experiment K-6-13. Morphological and biochemical examination of heart tissue. Part 1: Effects of microgravity on the myocardial fine structure of rats flown on Cosmos 1887. Ultrastructure studies. Part 2: Cellular distribution of cyclic ampdependent protein kinase regulatory subunits in heart muscle of rats flown on Cosmos 1887 [R] . Philpott, D. E., Kato, K., Stevenson, J., 1990

机译：实验K-6-13。心脏组织的形态学和生化检查。第1部分：微重力对Cosmos 1887上飞行的大鼠心肌细微结构的影响。超微结构研究。第2部分：在Cosmos 1887上飞行的大鼠心肌中环状独立蛋白激酶调节亚基的细胞分布

Crystal structure of rat GTP cyclohydrolase I feedback regulatory protein, GFRP

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