• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Molecular and Engineering Materials >DOPAMINE SERVES AS A STABLE SURFACE MODIFIER FOR IRON OXIDE NANOPARTICLES
【24h】

DOPAMINE SERVES AS A STABLE SURFACE MODIFIER FOR IRON OXIDE NANOPARTICLES

机译：多巴胺可作为氧化铁纳米粒子的稳定表面改性剂

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Iron oxide nanoparticles are an important class of nanomaterials in a broad range of biomedical applications because of their superparamagnetism and biocompatibility. The success of biomedical applications of iron oxide nanoparticles relies on the particles' surface functionalization, which requires robust and versatile surface anchors. Here, we report on a detailed examination of the dopamine-based surface modification of iron oxide nanoparticles. We used dopamine (2-(3,4-dihydroxyphenyl)ethylamine) and L-dopa (3,4-dihydroxy-L-phenylalanine) as two surface modifiers and chose Fe_2O_3 hollow nanoparticles and Fe_3O_4 nanoparticles as two representative substrates. Optical and TEM images showed that iron oxide nanoparticles dispersed very well in water after surface modification. The analysis of the UV-Vis spectra indicated that dopamine and L-dopa are stable after being immobilized on the surface of iron oxide nanoparticles when the pH value of the environment is about 7. The magnetic properties analysis further showed that the blocking temperature of the dopamine- or L-dopa-decorated iron oxide nanoparticles hardly-changed over 20 days, confirming long-term stability of these surface modified nanoparticles. Cell assay indicated that these dopamine- or L-dopa-modified iron oxide nanoparticles were biocompatible. These results confirm that dopamine serves as a stable modifier and a robust anchor to functionalize iron oxide nanoparticles in biomedical applications
机译：氧化铁纳米颗粒由于其超顺磁性和生物相容性，在广泛的生物医学应用中是一类重要的纳米材料。氧化铁纳米颗粒的生物医学应用的成功取决于颗粒的表面功能化，这需要坚固而通用的表面锚。在这里，我们报告氧化铁纳米粒子的基于多巴胺的表面改性的详细检查。我们使用多巴胺（2-（3,4-二羟基苯基）乙胺）和左旋多巴（3,4-二羟基-L-苯丙氨酸）作为两种表面改性剂，并选择Fe_2O_3空心纳米颗粒和Fe_3O_4纳米颗粒作为两种代表性的底物。光学和TEM图像显示，表面改性后，氧化铁纳米粒子在水中的分散性非常好。 UV-Vis光谱分析表明，当环境的pH值约为7时，多巴胺和L-多巴被固定在氧化铁纳米颗粒表面后是稳定的。磁性能分析进一步表明，多巴胺和L-多巴的封闭温度多巴胺或L-多巴修饰的氧化铁纳米粒子在20天内几乎没有变化，证实了这些表面改性的纳米粒子的长期稳定性。细胞测定表明，这些多巴胺或左旋多巴修饰的氧化铁纳米颗粒具有生物相容性。这些结果证实，多巴胺可作为稳定的改性剂和牢固的锚定剂，以在生物医学应用中官能化氧化铁纳米颗粒。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号