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首页> 外文期刊>Journal of Molecular Biology >MOLECULAR PHYLOGENY AND EVOLUTIONARY TIMESCALE FOR THE FAMILY OF MAMMALIAN HERPESVIRUSES
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MOLECULAR PHYLOGENY AND EVOLUTIONARY TIMESCALE FOR THE FAMILY OF MAMMALIAN HERPESVIRUSES

机译：哺乳动物疱疹病毒家族的分子系统发育和进化时间表

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A detailed phylogenetic analysis for mammalian members of the family Herpesviridae, based on molecular sequences is reported. Sets of encoded amino acid sequences were collected for eight well conserved genes that are common to mammalian herpesviruses. Phylogenetic trees were inferred from alignments of these sequence sets using both maximum parsimony and distance methods, and evaluated by bootstrap analysis. In all cases the three recognised subfamilies (Alpha-, Beta- and Gammaherpesvirinae), and major sublineages in each subfamily, were clearly distinguished, but within sublineages some finer details of branching were incompletely resolved. Multiple-gene sets were assembled to give a broadly based tree. The root position of the tree was estimated by assuming a constant molecular clock and also by analysis of one herpesviral gene set (that encoding uracil-DNA glycosylase) using cellular homologues as outgroups. Both procedures placed the root between the Alphaherpesvirinae and the other two subfamilies. Substitution rates were calculated for the combined gene sets based on a previous estimate for alphaherpesviral UL27 genes, where the time base had been obtained according to the hypothesis of cospeciation of virus and host lineages. Assuming a constant molecular clock, it was then estimated that the three subfamilies arose approximately 180 to 220 million years ago, that major sublineages within subfamilies were probably generated before the mammalian radiation of 80 to 60 million years ago, and that speciations within sublineages took place in the last 80 million years, probably with a major component of cospeciation with host lineages. [References: 61]
机译：报告了基于分子序列的疱疹病毒科哺乳动物成员的详细系统发育分析。收集了八个编码良好的保守基因的编码氨基酸序列集，这些基因是哺乳动物疱疹病毒共有的。使用最大简约法和距离法从这些序列集的比对推断出系统发生树，并通过自举分析对其进行评估。在所有情况下，三个公认的亚科（α，β和γ疱疹病毒科）以及每个亚科的主要亚系都被清楚地区分，但在亚系中，一些更精细的分支细节无法完全解析。组装多基因集以提供基础广泛的树。通过假定一个恒定的分子钟并通过使用细胞同源物作为一组对一个疱疹病毒基因集（编码尿嘧啶-DNA糖基化酶的基因集）进行分析来估计树的根部位置。两种方法都将根源放置在Alphaherpesvirinae和其他两个亚科之间。基于先前对α疱疹病毒UL27基因的估计，计算了组合基因集的替代率，其中根据病毒和宿主谱系共存的假设获得了时基。假设分子钟恒定，则可以估计这三个亚科大约出现于180至2.2亿年前，该亚科内的主要亚系可能是在80到6000万年前的哺乳动物辐射之前产生的，并且亚系内的物种形成已经发生。在过去的8000万年中，可能与宿主血统共存。 [参考：61]

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