Genetic Perturbations of RNA Reveal Structure-based Recognition in Protein-RNA Interaction.

Choi H; Otten S; Schneider J; McClain WH

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Genetic Perturbations of RNA Reveal Structure-based Recognition in Protein-RNA Interaction.

机译：RNA的遗传扰动揭示了蛋白质-RNA相互作用中基于结构的识别。

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Protein-RNA recognition is an essential foundation of cellular processes, yet much remains unknown about these important interactions. The recognition between aminoacyl-tRNA synthetases and their cognate tRNA substrates is highly specific and essential for cell viability, due to the necessity for accurate translation of the genetic code into protein sequences. We selected an active tRNA that is highly mutated in the recognition nucleotides of the acceptor stem region in the alanine system. The functional properties of this mutant and its secondary derivatives demonstrate that recognition cannot be reduced to isolated structural elements, but rather the amino acid acceptor stem is being recognized as a unit.

机译：蛋白质-RNA识别是细胞过程的重要基础，但对于这些重要的相互作用尚不清楚。氨酰基-tRNA合成酶及其同源tRNA底物之间的识别是高度特异性的，对于细胞活力至关重要，这是因为必须将遗传密码准确翻译成蛋白质序列。我们选择了在丙氨酸系统中受体茎区的识别核苷酸中高度突变的活性tRNA。该突变体及其二级衍生物的功能特性表明，识别不能还原为分离的结构元件，而是将氨基酸受体茎识别为一个单元。

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《Journal of Molecular Biology》 |2002年第4期|共4页
作者
Choi H; Otten S; Schneider J; McClain WH;
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正文语种 eng
中图分类分子生物学;
关键词
Protein measurement; RNA; Transfer; Recognition (Psychology); Genetic; RNA; 转移;

机译：Protein measurement;RNA;Transfer;Recognition (Psychology);Genetic;RNA;转移;

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专利

1. Genetic Perturbations of RNA Reveal Structure-based Recognition in Protein-RNA Interaction. [J] . Choi H, Otten S, Schneider J, Journal of Molecular Biology . 2002,第4期

机译：RNA的遗传扰动揭示了蛋白质-RNA相互作用中基于结构的识别。
2. RCK: accurate and efficient inference of sequence- and structure-based protein-RNA binding models from RNAcompete data [J] . Orenstein Yaron, Wang Yuhao, Berger Bonnie Bioinformatics . 2016,第12期

机译：RCK：从RNA竞争数据中准确有效地推断基于序列和结构的蛋白质-RNA结合模型
3. An integrative approach combining noncovalent mass spectrometry, enzyme kinetics and X-ray crystallography to decipher Tgt protein-protein and protein-RNA interaction. [J] . Ritschel T, Atmanene C, Reuter K Journal of Molecular Biology . 2009,第4期

机译：一种结合了非共价质谱，酶动力学和X射线晶体学的综合方法来破译Tgt蛋白质-蛋白质和蛋白质-RNA相互作用。
4. Systematic identification of local structure binding motifs in protein-RNA recognition [C] . Liu Zhi-Ping International Conference on Systems Biology . 2014

机译：系统识别蛋白质-RNA识别中的局部结构结合基序
5. RNA recognition by helix-threading peptides and their utility as inhibitors of protein-RNA interactions. [D] . Gooch, Barry David. 2006

机译：螺旋线肽对RNA的识别及其作为蛋白质-RNA相互作用抑制剂的效用。
6. Peptide models of the Tat-TAR protein-RNA interaction. [O] . A. D. Frankel 1992

机译：Tat-TAR蛋白-RNA相互作用的肽模型。
7. 2P304 Structure-based bioinformatics analyses of protein-RNA interface toward developing a computational method to predict protein-RNA interface [O] . Oanh Kim, K. Yura, N. Go 2005

机译：基于2P304基于结构的生物信息学分析蛋白-RNA接口朝向制定计算方法预测蛋白-RNA接口

Genetic Perturbations of RNA Reveal Structure-based Recognition in Protein-RNA Interaction.

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