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首页> 外文期刊>Journal of Molecular Biology >The crystal structure of annexin A8 is similar to that of annexin A3.
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The crystal structure of annexin A8 is similar to that of annexin A3.

机译：膜联蛋白A8的晶体结构类似于膜联蛋白A3的晶体结构。

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摘要

Annexin A8 is a relatively infrequent and poorly studied member of this large family of calcium-binding and membrane-binding proteins. It is, however, associated with a specific disease, acute promyelocytic leukemia. We have solved its three-dimensional structure, which includes a moderately long and intact N terminus. The structure is closest to that of annexin A3 and highlights several important regions of inherent flexibility in the annexin molecule. The N terminus resembles that of annexin A3, as it lies along the concave surface of the molecule and inserts partially into the hydrophilic channel in its centre. Since both annexins A3 and A8 are expressed in promyelocytic cells during their differentiation, the similarity in their structures might suggest a functional relationship.
机译：Annexin A8是这个钙结合和膜结合蛋白大家族中相对罕见且研究较少的成员。然而，它与一种特定的疾病，急性早幼粒细胞白血病有关。我们已经解决了它的三维结构，其中包括一个中等长度且完整的N末端。该结构最接近膜联蛋白A3的结构，并突出了膜联蛋白分子固有的柔性的几个重要区域。 N末端与膜联蛋白A3的末端相似，因为它沿着分子的凹面，并部分插入其中心的亲水通道中。由于膜联蛋白A3和A8在分化过程中均在早幼粒细胞中表达，因此它们结构的相似性可能暗示了功能关系。

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