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首页> 外文期刊>Journal of Molecular Biology >REGULATION AND TRAFFICKING OF THREE DISTINCT 18 S RIBOSOMAL RNAS DURING DEVELOPMENT OF THE MALARIA PARASITE
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REGULATION AND TRAFFICKING OF THREE DISTINCT 18 S RIBOSOMAL RNAS DURING DEVELOPMENT OF THE MALARIA PARASITE

机译：疟疾寄生虫发育过程中三种不同的18 S核糖体RNA的调控和运输

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The human malaria parasite Plasmodium vivax has been shown to regulate the transcription of two distinct 18 RNAs during development. Here we show a third and distinctive type of ribosome that is present shortly after zygote formation, a transcriptional pattern of ribosome types that relates closely to the developmental state of the parasite and a phenomenon that separates ribosomal types at a critical phase of maturation. The A-type ribosome is predominantly found in infected erythrocytes of the vertebrate and the mosquito blood meal. Transcripts from the A gene are replaced by transcripts from another locus, the O gene, shortly after fertilization and increase in number as the parasite develops on the mosquito midgut. Transcripts from another locus, the S gene, begins as the oocyst form of the parasite matures. RNA transcripts from the S gene are preferentially included in sporozoites that bud off from the oocyst and migrate to the salivary gland while the O gene transcripts are left within the oocyst. Although all three genes are typically eukaryotic in structure, the O gene transcript, described here, varies from the other two in core regions of the rRNA that are involved in mRNA decoding and translational termination. We now can correlate developmental progression of the parasite with changes in regions of rRNA sequence that are broadly conserved, where sequence alterations have been related to function in other systems and whose effects can be studied outside of Plasm odium. This should allow assessment of the role of translational control in parasite development. (C) 1997 Academic Press Limited. [References: 33]
机译：人类疟原虫间日疟原虫已显示在发育过程中调节两个不同的18 RNA的转录。在这里，我们显示了合子形成后不久出现的第三种和独特的核糖体类型，与寄生虫的发育状态密切相关的核糖体类型的转录模式，以及在成熟的关键阶段分离核糖体类型的现象。 A型核糖体主要存在于脊椎动物和蚊子血粉的感染红细胞中。受精后不久，来自A基因的转录物被来自另一个基因座的基因O基因的转录物取代，并且随着寄生虫在蚊子中肠上的生长而数量增加。随着寄生虫卵囊形式的成熟，来自另一个基因座S基因的转录本开始。来自S基因的RNA转录物优先包含在子孢子中，子孢子从卵囊中萌芽并迁移到唾液腺，而O基因转录物则留在卵囊中。尽管这三个基因通常在结构上都是真核的，但此处描述的O基因转录本不同于其他两个在rRNA核心区域中涉及mRNA解码和翻译终止的区域。现在，我们可以将寄生虫的发育进程与广泛保守的rRNA序列区域的变化相关联，在该区域中，序列改变与其他系统中的功能相关，其作用可以在血浆中进行研究。这应该可以评估翻译控制在寄生虫发育中的作用。 （C）1997 Academic Press Limited。 [参考：33]

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