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THE AVIAN ADENOVIRUS PENTON - TWO FIBRES AND ONE BASE

机译：AVIAN ADENOVIRUS PENTON-两根纤维和一个底座

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摘要

The penton capsomer of mammalian adenoviruses consists of a trimeric, long and thin fibre inserted into a pentameric base. The avian adenoviruses possess a penton which presents another symmetry mismatch: each pentameric base is associated with two fibres. Here we have studied the morphology of the penton of CELO virus, an avian adenovirus, and we have determined the sequence of both fibres, one long and one short. The short fibre is probably associated with the base in the same way as the mammalian viral fibres and we will discuss how the long fibre could be attached. The shafts of all known adenovirus fibres consist of a series of 15-residue repeats. The avian virus fibres show a more complicated and less regular shaft repeat structure with single, double and triple repeats. The sequences of the receptor binding (head) domains of both fibres are very different from all other known fibre head domains and very different from each other, suggesting that the two fibres might bind to different receptors. The genome organization of the sequenced region is rather different from that in human adenoviruses. In particular, a region homologous to the human virus E3 region was not found at the position where it normally occurs in the human virus genome. (C) 1995 Academic Press Limited [References: 33]
机译：哺乳动物腺病毒的戊糖衣壳异构体由插入五聚体碱基的三聚体，长而细的纤维组成。禽腺病毒的戊烯具有另一个对称错配：每个五聚体碱基与两条纤维相关。在这里，我们研究了禽腺病毒CELO病毒的戊烯的形态，并确定了两种纤维的长度和长度。短纤维可能以与哺乳动物病毒纤维相同的方式与碱基结合，我们将讨论如何连接长纤维。所有已知的腺病毒纤维的杆身由一系列15个残基重复序列组成。禽病毒纤维显示出更复杂且规则性较差的杆重复结构，具有单，双和三重重复。两种纤维的受体结合（头部）结构域的序列与所有其他已知的纤维头部结构域都非常不同，并且彼此也非常不同，这表明两条纤维可能会结合不同的受体。测序区域的基因组组织与人腺病毒中的显着不同。特别地，在人病毒基因组中通常出现的位置未发现与人病毒E3区域同源的区域。 （C）1995 Academic Press Limited [参考文献：33]

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