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首页> 外文期刊>Journal of Molecular Biology >Canonical antigen-binding loop structures in immunoglobulins: more structures, more canonical classes?
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Canonical antigen-binding loop structures in immunoglobulins: more structures, more canonical classes?

机译：免疫球蛋白中的规范性抗原结合环结构：更多的结构，更多的规范类别？

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摘要

Grafting the antigen-binding loops onto a human antibody scaffold is a widely used technique to humanise murine antibodies. The success of this approach depends largely on the observation that the antigen-binding loops adopt only a limited number of canonical structures. Identification of the correct canonical structure is therefore essential. Algorithms that predict the main-chain conformation of the hypervariable loops using only the amino acid sequence often provide this information. Here, we describe new canonical loop conformations for the hypervariable regions H1 and H2 as found in single-domain antibody fragments of dromedaries or llama. Although the occurrence of these new loop conformations was not predicted by the algorithms used, it seems that they could occur in human or mouse antigen-binding loops. Their discovery indicates that the currently used set of canonical structures is incomplete and that the prediction algorithms should be extended to include these new structures. Copyright 2000 Academic Press.
机译：将抗原结合环嫁接到人抗体支架上是人源化鼠抗体的广泛使用的技术。这种方法的成功很大程度上取决于观察到的抗原结合环仅采用有限数量的规范结构。因此，确定正确的规范结构至关重要。仅使用氨基酸序列来预测高变环的主链构象的算法通常会提供此信息。在这里，我们描述了在单峰骆驼或美洲驼的单域抗体片段中发现的高变区H1和H2的新规范环构象。尽管这些新的环构象的出现不是由所使用的算法预测的，但似乎它们可能出现在人或小鼠的抗原结合环中。他们的发现表明，当前使用的规范结构集不完整，预测算法应扩展为包括这些新结构。版权所有2000学术出版社。

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