• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Molecular Biology >Theoretical study on mutation-induced activation of the luteinizing hormone receptor.
【24h】

Theoretical study on mutation-induced activation of the luteinizing hormone receptor.

机译：黄体生成激素受体突变诱导激活的理论研究。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Here, three-dimensional model building and molecular dynamics simulations of the luteinizing hormone receptor have been employed to generate hypotheses about the molecular mechanisms underlying the activation of the receptor induced by naturally occurring activating mutations. The comparative analysis of the wild-type receptor and of 16 constitutively active or inactive mutants has been instrumental in inferring the structural/dynamic features which could characterize the inactive and the active forms of the receptor. These features have been also employed for predicting the functional behavior of new receptor mutants.The results of this study might provide a structural framework to interpret the pathological effects induced by mutations of the luteinizing hormone receptor. In addition, the proposed theoretical model could be useful for engineering new mutations or ligands able to modulate receptor function. Copyright 2000 Academic Press.
机译：在这里，黄体生成激素受体的三维模型建立和分子动力学模拟已被用来产生关于由自然发生的激活突变诱导的受体激活的分子机制的假设。对野生型受体和16个组成性有活性或无活性突变体的比较分析有助于推断可表征受体无活性和活性形式的结构/动力学特征。这些特征也已被用于预测新受体突变体的功能行为。这项研究的结果可能提供一个结构框架，以解释由黄体激素受体突变引起的病理效应。此外，提出的理论模型可能对工程改造能够调节受体功能的新突变或配体有用。版权所有2000学术出版社。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号