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首页> 外文期刊>Journal of Materials Chemistry, B. materials for biology and medicine >Mn~(2+)-doped NaYF4:Yb/Er upconversion nanoparticles with amplified electrogenerated chemiluminescence for tumor biomarker detection
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Mn~(2+)-doped NaYF4:Yb/Er upconversion nanoparticles with amplified electrogenerated chemiluminescence for tumor biomarker detection

机译：Mn〜（2+）掺杂的NaYF4：Yb / Er上转换纳米粒子，具有放大的电化学发光能力，用于肿瘤生物标志物的检测

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Chemiluminescence was used as an excitation tight source to construct a universal photoelectrochemical platform based on Mn~(2+)-doped NaYF4:Yb/Er upconversion nanoparticles, which greatly improves the electrochemiluminescence intensity and offers more stable cathodic signals compared to pure NaYF4:Yb/Er NPs. Here, we report for the first time the ECL behaviors of Mn~(2+)-doped NaYF4:Yb/Er NPs, which were synthesized via a facile strategy. Mn~(2+) doping resulted in a 4-fold ECL~-intensity enhancement of NaYF4:Yb/Er. The characteristics of Mn~(2+)-doped NaYF4:Yb/Er nanocomposites were obtained using transmission electron microscopy (TEM), energy dispersive X-ray spectrometer (EDS), and fluorescence spectra. After all the results had indicated that NaYF4:Yb/Er upconversion nanoparticles were successfully doped with Mn~(2+), the electrochemiluminescence platform was built. The as-prepared NaYF4:Yb/Er NPs were rendered water-soluble and then employed as ECL emitters for carcinoembryonic antigen (CEA) determination. The results indicated that the modified electrode can be used to determine CEA without interference from non-specific proteins, with a low detection limit of 5.2 pg mL~(-1). The biosensor can also be used for quantification of the CEA concentration in real samples.
机译：化学发光被用作激发光致密光源，构建了一个基于Mn〜（2+）掺杂的NaYF4：Yb / Er上转换纳米粒子的通用光电化学平台，与纯NaYF4：Yb相比，它极大地提高了化学发光强度并提供了更稳定的阴极信号。 / Er NP。在这里，我们首次报告了通过简便策略合成的Mn〜（2+）掺杂的NaYF4：Yb / Er NPs的ECL行为。 Mn〜（2+）掺杂使NaYF4：Yb / Er的ECL〜强度提高了4倍。利用透射电子显微镜（TEM），能量色散X射线能谱仪（EDS）和荧光光谱获得了掺Mn〜（2+）的NaYF4：Yb / Er纳米复合材料的特征。在所有结果表明NaYF4：Yb / Er上转换纳米粒子成功掺杂了Mn〜（2+）之后，建立了电化学发光平台。使制备好的NaYF4：Yb / Er NP溶于水，然后用作ECL发射体以确定癌胚抗原（CEA）。结果表明，修饰电极可用于CEA的检测，不受非特异性蛋白质的干扰，检出限低至5.2 pg mL〜（-1）。该生物传感器还可以用于定量真实样品中的CEA浓度。

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