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首页> 外文期刊>Journal of natural toxins >Renal alterations induced by Cerastes cerastes cerastes venom.
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Renal alterations induced by Cerastes cerastes cerastes venom.

机译：Cerastes cerastes诱发的肾脏改变cerastes毒液。

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The purpose of the present study was to determine the structural and functional alterations in the kidneys of rats experimentally envenomated with the viper Cerastes cerastes cerastes. The effects of a single i.p. sub-LD50 (0.73 mg Kg-1) for 24 hr and 7 consecutive doses (0.42 mg Kg-1; daily injection) on the kidneys of rats were studied. Histological examination of the kidneys in envenomated rats revealed the presence of atrophied glomeruli, cloudy materials within the proximal and distal convoluted tubules, atrophy and hypertrophy of quite a large number of tubular nuclei and mesangial proliferation. Hemorrhagic areas, dilated thrombosed vessels, fibrosis, and mitotic indices were also among the histopathological alterations in the renal cortex of the venom-injected animal groups. Electron microscopical findings revealed the presence of cell debris and electron dense materials within the lumen of the distal and proximal convoluted tubules. The cell lining of the proximal convoluted tubules underwent variable degrees of degeneration, and most of their intracellular organelles were deteriorated. The glomeruli contained quite large areas of mesangial matrix, and the lumen of most of their blood capillaries enclosed a moderately electron dense matrix. The cells of the endothelial lining of these capillaries were hypertrophied, and most of them lost their integrity and diffused with the surrounding matrix of the capillary lumen. Several leukocytic aggregates were observed in the intertubular spaces and blood capillaries. In addition, the erythrocytes of most of these capillaries displayed different patterns of electron density.
机译：本研究的目的是确定在实验中用毒蛇Cerastes cerastes cerastes毒死的大鼠肾脏的结构和功能改变。单次i.p.的影响研究了大鼠肾脏中亚半数致死剂量（LD3）（0.73 mg Kg-1）24小时和连续7次给药（0.42 mg Kg-1;每日注射）的情况。对被灌胃的大鼠的肾脏进行组织学检查，发现存在萎缩性肾小球，近端和远端弯曲小管内混浊的物质，相当数量的肾小管核的萎缩和肥大和肾小球膜增生。出血部位，扩张的血栓血管，纤维化和有丝分裂指数也是注射了毒液的动物组肾皮质的组织病理学改变。电子显微镜的发现揭示了在远端和近端的曲折小管腔内存在细胞碎片和电子致密物质。近曲小管的细胞内膜经历了不同程度的变性，并且它们的大多数细胞内细胞器都恶化了。肾小球包含很大面积的肾小球系膜基质，并且它们的大多数毛细血管的内腔都包围着中等电子密度的基质。这些毛细血管的内皮细胞是肥大的，大多数失去了完整性，并随周围的毛细血管腔基质扩散。在肾小管间隙和毛细血管中观察到一些白细胞聚集体。另外，大多数这些毛细血管的红细胞显示出不同的电子密度模式。

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