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首页> 外文期刊>Journal of natural toxins >Comparison of phytotoxicity and mammalian cytotoxicity of nontrichothecene mycotoxins.
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Comparison of phytotoxicity and mammalian cytotoxicity of nontrichothecene mycotoxins.

机译：非三茂金属霉菌毒素的植物毒性和哺乳动物细胞毒性的比较。

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摘要

The phytotoxicity and mammalian cytotoxicity of four nontrichothecene mycotoxins (apicidin, sambutoxin, wortmannin, HC-toxin) were compared. Phytotoxicity was evaluated in terms of electrolyte leakage, growth inhibition, and reduction in chlorophyll content. Based on the parameters evaluated, the relative order of phytotoxicity to duckweed (Lemna pausicostata L.) was wortmannin > HC-toxin > apicidin sambutoxin. A 48-hr exposure to 10 microM wortmannin, HC-toxin or apicidin caused electrolyte leakage from duckweed. The IC50 values for growth inhibition and chlorophyll reduction for wortmannin, HC-toxin, and apicidin were 0.2 and 2.6 microM, 15.4 and 12.6 microM, and 27.7 and 45.3 microM, respectively. Based on the parameters measured, a 72-hr exposure to 100 microM sambutoxin was not toxic to duckweed. Kudzu (Pueraria lobata L.) leaf disc assays revealed a similar trend in relative toxicities, but higher mycotoxin concentrations were required to elicit phytotoxic effects compared to duckweed. All four mycotoxins were cytotoxic to four mammalian cell cultures. However, in contrast to plants, wortmannin was the least toxic (IC50 = 10 to 20 microM) and sambutoxin exhibited a high level of toxicity (IC50 = 0.5 to 1 microM).
机译：比较了四种非trichothecene霉菌毒素（apicidin，sambutoxin，wortmannin，HC-毒素）的植物毒性和哺乳动物细胞毒性。根据电解质泄漏，生长抑制和叶绿素含量的减少来评估植物毒性。根据所评估的参数，对浮萍（Lemna pausicostata L.）的植物毒性的相对顺序为渥曼青霉素> HC-毒素>阿哌西丁>沙丁胺醇。暴露于10 microM渥曼青霉素，HC毒素或芹菜素中48小时会导致浮萍中的电解质泄漏。渥曼青霉素，HC毒素和阿皮啶的生长抑制和叶绿素减少的IC50值分别为0.2和2.6 microM，15.4和12.6 microM，27.7和45.3 microM。根据测得的参数，暴露于100 microM的sambutoxin中72小时对浮萍无毒。 Kudzu（Pueraria lobata L.）叶盘测定法显示出相对毒性的相似趋势，但是与浮萍相比，需要更高的真菌毒素浓度才能引起植物毒性作用。所有四种霉菌毒素对四种哺乳动物细胞培养物均具有细胞毒性。但是，与植物相反，渥曼青霉素的毒性最低（IC50 = 10至20 microM），而三丁氧辛显示出高水平的毒性（IC50 = 0.5至1 microM）。

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