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Synthesis and characterization of glass-ceramic microspheres for thermotherapy

机译:热疗用玻璃陶瓷微球的合成与表征

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摘要

Glass microspheres containing radionuclides are used to treat liver cancer. A promising alternative therapy is being developed based on the magnetic hyperthermia which is related to the heat supplied by a magnetic material under an alternating current magnetic field. The advantage of this option is that most of killed cells are cancer cells which are more susceptible to the temperature raise. In the present work aluminum iron silicate glasses containing minor glass modifiers and nucleating agents were synthesized as irregular shape particles which were further transformed in microspheres by using a petrol liquefied gas -oxygen torch. The optimized processing parameters which lead to microspheres that give a response to the magnetic field were determined. The dissolution rate in water at 90 °C was determined to be 3 × 10~(-8) g cm~(-2) min~(-1). The microsphere size distribution was determined by laser scattering. The crystalline phase responsible for the ferromagnetic response was identified as magnetite. Since this phase has a high saturation magnetization and high Curie temperature, it is potentially useful for biomedical applications. The hysteresis magnetic loop was measured for materials produced in different conditions, and some of them showed to be appropriated for thermotherapy. The ratio Fe~(3+)/Fe _(total) was determined by M?ssbauer spectroscopy.
机译:含有放射性核素的玻璃微球用于治疗肝癌。基于磁热疗正在开发有前途的替代疗法,该磁疗与在交流磁场下由磁性材料提供的热量有关。这种选择的优点是大多数被杀死的细胞是癌细胞,它们对温度升高更敏感。在本工作中,合成了含有次要玻璃改性剂和成核剂的硅酸铝铁玻璃,其为不规则形状的颗粒,并通过使用汽油液化气-氧气炬将其进一步转变成微球。确定了导致微球对磁场产生响应的优化处理参数。在90℃下在水中的溶解速率经测定为3×10-(-8)g cm-(-2)min-(-1)。通过激光散射确定微球尺寸分布。负责铁磁响应的结晶相被鉴定为磁铁矿。由于该相具有很高的饱和磁化强度和居里温度,因此对于生物医学应用可能很有用。测量了在不同条件下生产的材料的磁滞磁环,其中一些材料适用于热疗。 Fe〜(3 +)/ Fe_(总)之比通过Msssbauer光谱法测定。

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