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首页> 外文期刊>Biophysical Chemistry: An International Journal Devoted to the Physical Chemistry of Biological Phenomena >Inverted hexagonal and cubic phases induced by #alpha#-tocopherol in fully hydrated dispersions of dilauroylphosphatidylethanolamine
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Inverted hexagonal and cubic phases induced by #alpha#-tocopherol in fully hydrated dispersions of dilauroylphosphatidylethanolamine

机译：＃alpha＃-生育酚在二月桂酰磷脂酰乙醇胺的完全水合分散液中诱导的六方相和立方相反转

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摘要

The effect of #alpha#-tocopherol on the thermotropic phase behaviour and structure of aqueous dispersions of 1, 2-dilauoryl-sn-glycero-3-phosphoethanolamine was examined by synchrotron X-ray diffraction. The pure phospholipid exhibited a lamellar gel to liquid-crystal phase transition at 30 deg C on heating at 3 deg C min~-1 between 10 deg C and 90 deg C. The transition was reversible with a temperature hysteresis of 0.3 deg C on cooling. At temperatures less than 10 deg C only lamellar gel phase of the pure phospholipid was seen in co-dispersions of up to 20 mol % #alpha#-tocopherol. The presence of 2.5 mol % #alpha#-tocopherol caused the appearance of inverted hexagonal phase at temperatures just below the main phase transition temperature that co-existed with the lamellar gel phase. The intensity of scattering from the hexagonal-II phase increased with increasing proportion of #alpha#-tocopherol in the mixture and in proportions greater than 10 mol % it persisted at temperatures above the main transition and co-existed with the lamellar liquid-crystal phase of the pure phospholipid. At higher temperatures all co-dispersions containing up to 15 mol % #alpha#-tocopherol showed the presence of cubic phases. These phases indexed a Pn3m or Pn3 space grouping. When the proportion of #alpha#-tocopherol was increased to 20 mol % the only non-lamellar phase observed was inverted hexagonal phase. This phase co-existed with lamellar gel and liquid-crystal phases of the pure phospholipid, but was the only phase present at temperatures > 60 deg C. The X-ray diffraction data were used to construct a partial phase diagram of the lipid mixture in excess water between 10 deg C and 90 deg C and up to 20 mol % #alpha#-tocopherol in phospholipid.
机译：通过同步加速器X射线衍射检查了＃α＃-生育酚对1，2-二月桂基-sn-甘油-3-磷酸乙醇胺的水分散体的热致相行为和结构的影响。纯磷脂在10摄氏度和90摄氏度之间以3摄氏度min-1加热时，在30摄氏度时呈现出层状凝胶状转变为液晶的相变。在冷却时，温度滞后为0.3摄氏度时，该转变是可逆的。在低于10℃的温度下，仅磷脂的层状凝胶相在高达20mol％的＃α＃-生育酚的共分散体中被观察到。 2.5mol％的＃α＃-生育酚的存在导致在正好低于与层状凝胶相共存的主相转变温度的温度下出现倒六角相。随着混合物中＃alpha＃-生育酚比例的增加，六方相II的散射强度增加，并且比例大于10 mol％时，它在高于主转变温度的温度下持续存在，并与层状液晶相共存。纯磷脂。在更高的温度下，所有包含高达15 mol％＃α＃-生育酚的共分散液均显示立方相的存在。这些阶段为Pn3m或Pn3空间分组编制了索引。当＃α＃-生育酚的比例增加到20mol％时，观察到的唯一非层状相是倒六角相。该相与层状凝胶和纯磷脂的液晶相共存，但是温度> 60℃时存在的唯一相。X射线衍射数据用于构建脂质混合物的部分相图。介于10摄氏度至90摄氏度之间的过量水，以及高达20 mol％的＃alpha＃-生育酚在磷脂中。

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