...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of neuroendocrinology >Differential expression of oestrogen receptor alpha following reproductive experience in young and middle-aged female rats.
【24h】

Differential expression of oestrogen receptor alpha following reproductive experience in young and middle-aged female rats.

机译：雌雄激素受体α在年轻和中年雌性大鼠生殖过程后的差异表达。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Reproductive experience (i.e. pregnancy and lactation) alters a number of physiological and behavioural endpoints, many of which are related to reproductive function and are regulated by oestrogen. For example, reproductive experience significantly attenuates the oestradiol-induced prolactin surge on the afternoon of pro-oestrous and circulating oestradiol levels are reduced at this time. Although parity-related effects on oestrogen receptor (ER) alpha have been observed within the anterior pituitary, there are currently no data regarding possible parity-induced alterations in ERalpha in the brain. Thus, the present study aimed to examine the effect of parity on the expression of ERalpha in reproductively relevant brain regions. Moreover, because previous findings have demonstrated that the long-term effects of reproductive experience are often oestrous cycle-dependent, ERalpha was examined at two stages of the oestrous cycle (i.e. dioestrous and pro-oestrous). Finally, because the expression of ERalpha is significantly influenced by age, both young and middle-aged females were included in the present study. ERalpha status was determined using immunohistochemistry in select brain regions involved in the regulation of reproductive behaviour in age-matched, cycling primiparous (i.e. one pregnancy and lactation) and nulliparous females as well as in age-matched, noncycling (i.e. persistent oestrous) 12 month-old primiparous and nulliparous females. Significant shifts in ERalpha cell numbers were observed in the medial preoptic area and medial amygdala as a consequence of reproductive experience in an oestrous-dependent manner. These findings indicate that significant changes in ERalpha activity occur in the brain as a function of reproductive experience.
机译：生殖经验（即怀孕和哺乳）改变了许多生理和行为终点，其中许多与生殖功能有关并受雌激素调节。例如，生殖经验显着减弱了雌激素水平前下午由雌二醇诱导的催乳激素激增，此时循环中的雌二醇水平降低了。尽管在垂体前叶中观察到对雌激素受体（ER）α的奇偶性​​相关影响，但目前尚无关于大脑中ERα可能由奇偶性引起的变化的数据。因此，本研究旨在检验奇偶性对生殖相关大脑区域中ERalpha表达的影响。此外，由于先前的发现已经证明生殖经验的长期影响通常是依赖于雌性周期的，因此在雌性周期的两个阶段（即二发情和前雌性）检查了ERα。最后，由于ERalpha的表达受年龄的影响很大，因此本研究包括年轻和中年女性。使用免疫组织化学在参与调节年龄匹配的初次骑自行车（即一次妊娠和哺乳）和未生育的女性以及年龄匹配的非循环（即持久性雌性）的生殖行为的特定大脑区域中确定ERalpha状态初生和未产雌性。在生殖前部区域，以视雌激素依赖性的方式观察到，在视前内侧区域和杏仁核内侧，ERalpha细胞数量发生了显着变化。这些发现表明，根据生殖经验，大脑中的ERalpha活性发生了显着变化。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号