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首页> 外文期刊>Journal of neuroendocrinology >Involvement of 5-HT Receptors in the Regulation of Food Intake in Siberian Hamsters.
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Involvement of 5-HT Receptors in the Regulation of Food Intake in Siberian Hamsters.

机译：5-HT受体参与西伯利亚仓鼠食物摄入的调控。

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Abstract The Siberian hamster provides a physiological model for understanding the hypothalamic control of energy metabolism as it undergoes annual photoperiod-regulated cycles of body weight (i.e. fattening in summer, and catabolism of fat stores in winter). As a first step to investigate whether enhanced serotonergic (5-HT) tone might underlie the catabolic processes in short days, we investigated whether serotonergic stimulation can produce catabolic actions in fat hamsters housed in long days. Acute treatment with the serotonin reuptake inhibitor (+/-) fenfluramine (8 mg/kg, i.p.) produced a prolonged, dose-dependent reduction in food intake in both photoperiods. Behavioural observations and radiotelemetry analyses revealed that this anorectic effect of fenfluramine was associated with short-term increases in locomotor activity and in core body temperature. In a subsequent series of studies, hamsters were pretreated with the 5-HT(2C) receptor antagonist SB242084 (4 mg/kg, i.p.). This 5-HT(2C) receptor antagonist completely blocked the anorectic actions of fenfluramine, but did not decrease the hyperthermia or hyperlocomotion induced by fenfluramine; thus, the anorectic actions of fenfluramine probably reflect actions via the 5-HT(2C) receptor. Consistent with these observations, treatment of hamsters with the 5-HT(2C) receptor agonist VER 3323 (10 mg/kg, i.p.) or the 5-HT(1B/2C) receptor agonist mCPP (3 mg/kg, i.p.) reduced food intake. The response to manipulation of serotonergic pathways was not affected by the ambient photoperiod in any of these studies. We conclude that the anorectic actions of fenfluramine are not an indirect consequence of serotonergic actions on arousal pathways, and that its actions on feeding in the Siberian hamster are most likely to be mediated by the 5-HT(2C) receptor.
机译：摘要西伯利亚仓鼠提供了一个生理模型，以了解下丘脑对能量代谢的控制，因为它经历了每年的光周期调节的体重循环（即夏天增肥，冬天脂肪分解代谢）。作为调查增强的血清素能（5-HT）音调是否可能在短时间内分解代谢过程的第一步，我们调查了血清素能刺激是否可以在长期饲养的脂肪仓鼠中产生分解代谢作用。血清素再摄取抑制剂（+/-）芬氟拉明（8 mg / kg，i.p.）的急性治疗导致两种光周期食物摄入量的延长，剂量依赖性降低。行为观察和无线电遥测分析表明，芬氟拉明的厌食作用与运动活动和核心体温的短期增加有关。在随后的一系列研究中，仓鼠用5-HT（2C）受体拮抗剂SB242084（4 mg / kg，i.p.）进行了预处理。这种5-HT（2C）受体拮抗剂完全阻断了芬氟拉明的厌食作用，但没有降低芬氟拉明引起的体温过高或过高。因此，芬氟拉明的厌食作用可能反映了通过5-HT（2C）受体的作用。与这些观察结果一致，减少了使用5-HT（2C）受体激动剂VER 3323（10 mg / kg，ip）或5-HT（1B / 2C）受体激动剂mCPP（3 mg / kg，ip）对仓鼠的治疗食物的摄入量。在任何这些研究中，对血清素能途径操纵的反应均不受环境光周期的影响。我们得出的结论是，芬氟拉明的厌食作用不是血清素能对唤醒途径的间接作用，并且其对进食西伯利亚仓鼠的作用最有可能是由5-HT（2C）受体介导的。

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