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首页> 外文期刊>Journal of neuroendocrinology >Puberty onset in female rats: relationship with fat intake, ovarian steroids and the peptides, galanin and enkephalin, in the paraventricular and medial preoptic nuclei.
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Puberty onset in female rats: relationship with fat intake, ovarian steroids and the peptides, galanin and enkephalin, in the paraventricular and medial preoptic nuclei.

机译：雌性大鼠的青春期发作：与心室旁和视前内侧核中的脂肪摄入，卵巢类固醇以及肽，甘丙肽和脑啡肽的关系。

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摘要

Puberty is a time of rapid change, including a marked increase in fat consumption and body fat accrual, particularly in females. The mechanisms underlying these changes are unknown. Building on the results obtained in adult rats, the present study in pubertal rats focused on the orexigenic peptides, galanin (GAL) and enkephalin (ENK), in the paraventricular nucleus (PVN) and medial preoptic nucleus (MPN), which are known to be responsive to female steroids and have a role in both energy balance and reproductive function. The present study examined female rats maintained on pure macronutrient diets from before weaning (day 15) to day 70. After an initial burst in protein intake (days 21-35), rats showed an increase, specifically in preference for fat, from 15% to 30%. In rats examined at different ages before (day 30) and after (days 45 and 60) puberty, this rise in fat intake was associated with a marked increase, from days 30-45, in levels of oestradiol and progesterone and in GAL and ENK mRNA or peptide levels, specifically in the PVN and MPN, but not other hypothalamic areas examined. This positive relationship with increased fat intake, steroids and peptides across ages was also observed when comparing pubertal rats that naturally preferred fat (> 25% of total diet) with those consuming little fat (< 15%) or rats that reached puberty at an early age (days 30-34) with those that were late (days 37-40). These rats with early puberty onset exhibited a strong fat preference 3-4 days before vaginal opening, which was positively related to steroid levels, GAL, fat intake and body fat accrual after puberty. These findings suggest that, in addition to providing a signal for puberty onset, early fat ingestion acting through mechanisms involving the steroids and orexigenic peptides may be related to long-term patterns of eating and body weight regulation.
机译：青春期是一个快速变化的时期，其中包括脂肪消耗和人体脂肪累积显着增加，尤其是女性。这些变化的潜在机制尚不清楚。基于成年大鼠获得的结果，目前在青春期大鼠中的研究集中于室旁核（PVN）和视前内侧核（MPN）的致畸肽，甘丙肽（GAL）和脑啡肽（ENK）。对女性类固醇有反应，并在能量平衡和生殖功能中起作用。本研究检查了从断奶前（第15天）到第70天保持纯正大量营养饮食的雌性大鼠。在蛋白质摄入量开始暴增（第21-35天）后，大鼠显示出增加，特别是脂肪增加了15％至30％。在青春期之前（第30天）和青春期之后（第45和60天）检查不同年龄的大鼠中，从30-45天开始，脂肪摄入的增加与雌二醇和孕酮以及GAL和ENK的水平显着增加有关mRNA或肽水平，特别是在PVN和MPN中，但不在其他检查的下丘脑区域。当比较自然偏爱脂肪（> 25％总饮食）的青春期大鼠与少食脂肪（<15％）的青春期大鼠或较早进入青春期的大鼠时，还观察到与年龄增长的脂肪摄入，类固醇和肽类增加呈正相关。年龄（第30-34天）和较晚的年龄（第37-40天）。这些青春期初期的大鼠在阴道开放前3-4天表现出强烈的脂肪偏爱性，这与类固醇水平，GAL，脂肪摄入和青春期后体内脂肪积累呈正相关。这些发现表明，除了提供青春期发作的信号外，通过涉及类固醇和致癌肽的机制进行的早期脂肪摄入可能与长期饮食和体重调节有关。

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