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首页> 外文期刊>Journal of neuroendocrinology >Hypothalamic Wnt Signalling and its Role in Energy Balance Regulation
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Hypothalamic Wnt Signalling and its Role in Energy Balance Regulation

机译：下丘脑Wnt信号及其在能量平衡调节中的作用

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摘要

Wnt signalling and its downstream effectors are well known for their roles in embryogenesis and tumourigenesis, including the regulation of cell proliferation, survival and differentiation. In the nervous system, Wnt signalling has been described mainly during embryonic development, although accumulating evidence suggests that it also plays a major role in adult brain morphogenesis and function. Studies have predominantly concentrated on memory formation in the hippocampus, although recent data indicate that Wnt signalling is also critical for neuroendocrine control of the developed hypothalamus, a brain centre that is key in energy balance regulation and whose dysfunction is implicated in metabolic disorders such as type 2 diabetes and obesity. Based on scattered findings that report the presence of Wnt molecules in the tanycytes and ependymal cells lining the third ventricle and arcuate nucleus neurones of the hypothalamus, their potential importance in key regions of food intake and body weight regulation has been investigated in recent studies. The present review brings together current knowledge on Wnt signalling in the hypothalamus of adult animals and discusses the evidence suggesting a key role for members of the Wnt signalling family in glucose and energy balance regulation in the hypothalamus in diet-induced and genetically obese (leptin deficient) mice. Aspects of Wnt signalling in seasonal (photoperiod sensitive) rodents are also highlighted, given the recent evidence indicating that the Wnt pathway in the hypothalamus is not only regulated by diet and leptin, but also by photoperiod in seasonal animals, which is connected to natural adaptive changes in food intake and body weight. Thus, Wnt signalling appears to be critical as a modulator for normal functioning of the physiological state in the healthy adult brain, and is also crucial for normal glucose and energy homeostasis where its dysregulation can lead to a range of metabolic disorders.
机译：Wnt信号及其下游效应物在胚胎发生和肿瘤发生中的作用是众所周知的，包括调节细胞增殖，存活和分化。在神经系统中，Wnt信号主要在胚胎发育过程中被描述，尽管越来越多的证据表明，Wnt信号在成人脑形态发生和功能中也起着重要作用。研究主要集中在海马的记忆形成上，尽管最近的数据表明Wnt信号对于神经发达的下丘脑的神经内分泌控制也很关键，下丘脑是能量平衡调节的关键大脑中枢，其功能障碍与代谢障碍有关，例如2型糖尿病。 2糖尿病与肥胖。基于分散的发现，这些发现报告了下丘脑的第三脑室和弓形核神经元内的单核细胞和室间隔细胞中存在Wnt分子，最近的研究已经研究了它们在食物摄入和体重调节关键区域的潜在重要性。本综述汇集了关于成年动物下丘脑中Wnt信号传导的最新知识，并讨论了证据，表明在饮食诱导和遗传性肥胖（瘦素缺乏）下丘脑中Wnt信号传导家族成员在葡萄糖和能量平衡调节中的关键作用。 ） 老鼠。鉴于最近的证据表明下丘脑中的Wnt途径不仅受饮食和瘦素的调节，而且季节性动物的光周期也受到调节​​，Wnt信号在季节性（对光周期敏感的）啮齿动物中的作用也得到了强调，这与自然适应性疾病有关食物摄入量和体重的变化。因此，Wnt信号传导似乎是健康成年人大脑中生理状态正常功能的调节剂，并且对于正常的葡萄糖和能量稳态也很关键，在正常情况下，葡萄糖和能量稳态失调会导致一系列代谢异常。

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