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首页> 外文期刊>Journal of neuroendocrinology >Social Novelty Investigation in the Juvenile Rat: Modulation by the mu-Opioid System
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Social Novelty Investigation in the Juvenile Rat: Modulation by the mu-Opioid System

机译：未成年大鼠的社会新颖性调查：由mu阿片类系统调节

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The drive to approach and explore novel conspecifics is inherent to social animals and may promote optimal social functioning. Juvenile animals seek out interactions with novel peers more frequently and find these interactions to be more rewarding than their adult counterparts. In the present study, we aimed to establish a behavioural paradigm to measure social novelty-seeking in juvenile rats and to determine the involvement of the opioid, dopamine, oxytocin and vasopressin systems in this behaviour. To this end, we developed the social novelty preference test to assess the preference of a juvenile rat to investigate a novel over a familiar (cage mate) conspecific. We show that across the juvenile period both male and female rats spend more time investigating a novel conspecific than a cage mate, independent of subject sex or repeated exposure to the test. We hypothesised that brain systems subserving social information processing ;and social motivation/reward (i.e. the opioid, dopamine, oxytocin, vasopressin systems) might support social novelty preference. To test this, receptor antagonists of each of these systems were administered i.c.v. prior to exposure to the social novelty preference test and, subsequently, to the social preference test, to examine the specificity of these effects. We find that mu-opioid receptor antagonism reduces novel social investigation in both the social novelty preference and social preference tests while leaving the investigation of a cage mate (social novelty preference test) or an object (social preference test) unaffected. In contrast, central blockade of dopamine D-2 receptors (with eticlopride), oxytocin receptors (with des-Gly-NH2, d(CH2)(5)[Tyr(Me)(2), Thr(4)] OVT) or vasopressin V1a receptors [with (CH2)(5)Tyr(Me-2) AVP] failed to alter social novelty preference or social preference. Overall, we have established a new behavioural test to study social novelty-seeking behaviour in the juvenile rat and show that the mu-opioid system facilitates this behaviour, possibly by reducing risk avoidance and enhancing the hedonic and/or motivational value of social novelty.
机译：接触和探索新物种的动力是社交动物所固有的，并且可以促进最佳的社交功能。幼兽更频繁地寻找与新颖同伴的互动，并发现这些互动比成年同伴更有价值。在本研究中，我们旨在建立一种行为范例，以测量未成年大鼠中寻求社交新颖性的行为，并确定阿片样物质，多巴胺，催产素和加压素系统参与这种行为的方式。为此，我们开发了社交新颖性偏好测试，以评估少年鼠对小说的熟悉程度（相对于笼养对象）的偏好。我们表明，在整个少年时期，雄性和雌性大鼠比笼伴侣花费更多的时间研究一种新颖的同种菌，而不受受试者性别或反复接触试验的影响。我们假设大脑系统支持社会信息处理;社会动机/奖励（即阿片类药物，多巴胺，催产素，加压素系统）可能支持社会新颖性偏好。为了对此进行测试，对这些系统中的每一个的受体拮抗剂进行静脉内给药。在接受社会新颖性偏好测试之前，随后进行社会偏好测试，以检查这些影响的特异性。我们发现，对阿片类药物受体的拮抗作用减少了社交新颖性偏好和社交偏好测试中的新型社交调查，同时不影响笼伴侣（社交新颖性偏好测试）或对象（社交偏好性测试）的调查。相比之下，对多巴胺D-2受体（与埃替普利），催产素受体（与des-Gly-NH2，d（CH2）（5）[Tyr（Me）（2），Thr（4）] OVT）进行中枢阻断。加压素V1a受体[具有（CH2）（5）Tyr（Me-2）AVP]未能改变社会新颖性偏好或社会偏好。总体而言，我们已经建立了一项新的行为测试，以研究少年大鼠中寻求社会新颖性的行为，并表明，μ阿片类药物系统可以通过减少风险规避和增强社会新颖性的享乐价值和/或动机价值来促进这一行为。

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