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首页> 外文期刊>Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology >Gammadelta T cell responses to activated T cells in multiple sclerosis patients induced by T cell vaccination.
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Gammadelta T cell responses to activated T cells in multiple sclerosis patients induced by T cell vaccination.

机译：T细胞疫苗诱导的多发性硬化症患者中Gammadelta T细胞对活化T细胞的反应。

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To explore the hypothesis that gammadelta T cells may regulate activated alphabeta T cells, we studied gammadelta T cell responses to alphabeta T cell clones in Multiple Sclerosis (MS) patients who received attenuated autologous autoreactive T cells. We recently conducted a pilot study of T cell vaccination with myelin basic protein reactive T cells in MS. Since T cell vaccination upregulates the anti-vaccine T cell responses, we evaluated gammadelta T cell reactivity towards the vaccine in the vaccinated patients. Lymphocytes were stimulated in vitro with irradiated vaccine cells and the responding lines were checked for the presence of gammadelta T cells. Our data demonstrate that in the majority of vaccinated MS patients gammadelta T cells expand upon stimulation with the vaccine cells. The responding gammadelta T cells were predominantly Vdelta1+/Vgamma1+, and represented diverse clonal origins. The gammadelta T cells could not inhibit in vitro proliferation of the vaccine T cells and displayed low cytotoxic reactivity towards the vaccine clones. However, they produced high levels of IL2, TNFalpha and IL10. These results indicate that gammadelta T cells can be stimulated by activated alphabeta T cells, and that these gammadelta T cell responses are upregulated after T cell vaccination. These findings suggest that gammadelta T cells are involved in peripheral mechanisms to control activated autoreactive T cells.
机译：为了探索γ-T细胞可能调节活化的字母T细胞的假说，我们研究了多发性硬化症（MS）患者中γ-T细胞对字母T细胞克隆的反应，这些患者接受了减毒的自体自身反应性T细胞。我们最近在MS中对髓鞘碱性蛋白反应性T细胞接种T细胞疫苗进行了初步研究。由于T细胞疫苗接种会上调抗疫苗T细胞应答，因此我们在接种疫苗的患者中评估了Gammadelta T细胞对疫苗的反应性。用辐照的疫苗细胞体外刺激淋巴细胞，并检查应答细胞系中是否存在γδT细胞。我们的数据表明，在大多数已接种MS的患者中，γT细胞在受到疫苗细胞刺激后会扩增。响应的γT细胞主要为Vdelta1 + / Vgamma1 +，代表多种克隆起源。 γT细胞不能抑制疫苗T细胞的体外增殖，并显示出对疫苗克隆的低细胞毒性反应性。然而，它们产生高水平的IL2，TNFα和IL10。这些结果表明，活化的字母T细胞可以刺激γ-T细胞，并且在接种T细胞后这些γ-T细胞应答被上调。这些发现表明，γδT细胞参与了控制活化的自身反应性T细胞的外周机制。

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