A role of the thymus and thymosin-alpha1 in brain NGF levels and NGF receptor expression.

Turrini P; Tirassa P; Vigneti E; Aloe L

首页> 外文期刊>Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology >A role of the thymus and thymosin-alpha1 in brain NGF levels and NGF receptor expression.

【24h】

A role of the thymus and thymosin-alpha1 in brain NGF levels and NGF receptor expression.

机译：胸腺和胸腺素α1在大脑NGF水平和NGF受体表达中的作用。

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Using neonatal rats we investigated the role of the thymus and thymosin-alpha1 (T-alpha1) in brain NGF levels, NGF receptor (p75NGFr) expression, as well as the activity of choline acetyl-transferase, a cholinergic enzyme regulated by NGF. It is shown that early postnatal thymectomy causes a decrease in NGF in the hippocampus and cortex and p75NGFr distribution in the basal forebrain cholinergic neurons (FBCN). Intracerebral T-alpha1 injection in thymectomized animals induces a recovery, albeit not complete, of both NGF and p75NGFr. These findings indicate that thymectomy affects both the brain NGF producing and responding cells and that T-alpha1 may be one of the thymic hormones involved in the regulation of cerebral NGF synthesis.

机译：我们使用新生大鼠调查了胸腺和胸腺素α1（T-alpha1）在大脑NGF水平，NGF受体（p75NGFr）表达以及胆碱乙酰基转移酶（一种由NGF调节的胆碱能酶）中的作用。研究表明，产后早期胸腺切除术会导致海马和皮质的NGF减少，以及基底前脑胆碱能神经元（FBCN）中的p75NGFr分布。在胸腺切除动物中脑内注射T-alpha1可以诱导NGF和p75NGFr的恢复，尽管不完全。这些发现表明，胸腺切除术会影响大脑NGF的产生和反应细胞，并且T-alpha1可能是参与调节大脑NGF合成的胸腺激素之一。

著录项

来源
《Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology》 |1998年第1期|共9页
作者
Turrini P; Tirassa P; Vigneti E; Aloe L;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类神经病学与精神病学;医学免疫学;
关键词
Adjuvants; Immunologic; Brain Chemistry; Nerve Growth Factors; Receptors; Nerve Growth Factor; 佐剂; 免疫; 脑化学; 神经生长因子; 受体; 神经生长因子; 胸腺素; 胸腺;

机译：Adjuvants;Immunologic;Brain Chemistry;Nerve Growth Factors;Receptors;Nerve Growth Factor;佐剂;免疫;脑化学;神经生长因子;受体;神经生长因子;胸腺素;胸腺;

相似文献

外文文献
中文文献
专利

1. A role of the thymus and thymosin-alpha1 in brain NGF levels and NGF receptor expression. [J] . Turrini P, Tirassa P, Vigneti E, Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology . 1998,第1期

机译：胸腺和胸腺素α1在大脑NGF水平和NGF受体表达中的作用。
2. Structural and ultrastructural localization of NGF and NGF receptors in the thymus of subjects affected by myasthenia gravis. [J] . Marinova TT, Velikova KK, Petrov DB, Autoimmunity . 2004,第8期

机译：NGF和NGF受体在重症肌无力患者胸腺中的结构和超微结构定位。
3. High-pressure physiological saline isotonic solution administration enhances brain NGF and NGF-receptors expression [J] . Salvinelli F., Frari V., Rocco M. L., European review for medical and pharmacological sciences. . 2015,第20期

机译：高压生理盐水等渗溶液给药可增强脑NGF和NGF受体的表达
4. Quantitative Effects of NGF Encapsulating PLGA Microsphere on Neurite Outgrowth at Single Cell Level [C] . Andrew Sweeney, Karen Burg, Mark Kindy, Society for Biomaterials Transaction Annual Meeting vol.29 pt.2 . 2006

机译：NGF包裹PLGA微球在单细胞水平对神经突生长的定量影响
5. Distribution of NGF receptors in the enteric nervous system of the rat colon: Selective loss of NGF sensitivity following experimental colitis. [D] . Lin, Chih-Ting Agueda. 2003

机译：NGF受体在大鼠结肠肠神经系统中的分布：实验性结肠炎后NGF敏感性的选择性丧失。
6. Relationship of APP mRNA transcripts and levels of NGF and low-affinity NGF receptors to behavioral measures of age-related cognitive dysfunction [O] . MD Lindner, SI Dworetzky, C Sampson, 1994

机译：APP mRNA转录本和NGF和低亲和力NGF受体水平与年龄相关性认知功能障碍的行为指标的关系
7. PRESENCE OF BOTH NEUROTROPHIC GROWTH FACTOR (NGF) AND NGF RECEPTORS (NGF-R) IN RAT ISLET CELLS IN CULTURE: ROLE OF NEUROTROPHIC FACTORS IN ISLET CELL DEVELOPMENT [O] . C Kanaka, R Scharfmann, P Czernichow 1993

机译：培养中大鼠胰岛细胞中的神经营养生长因子（NGF）和NGF受体（NGF-R）的存在：神经营养因子在胰岛细胞发育中的作用

A role of the thymus and thymosin-alpha1 in brain NGF levels and NGF receptor expression.

摘要

著录项

相似文献

相关主题

期刊订阅