• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology >Focal accumulation of cyclooxygenase-1 (COX-1) and COX-2 expressing cells in cerebral malaria.
【24h】

Focal accumulation of cyclooxygenase-1 (COX-1) and COX-2 expressing cells in cerebral malaria.

机译：大脑中的环氧合酶1（COX-1）和COX-2表达细胞的局部聚集。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Intravascular sequestration and altered cytokine expression patterns are key determinators of CNS lesion formation in patients with cerebral malaria (CM). Among others, altered prostaglandin concentrations were revealed by clinical trials in peripheral blood of CM patients. Prostaglandin synthesis is controlled by cyclooxygenases (COX, prostaglandin endoperoxide synthase, PGG/H synthase) and COX expression has been attributed a key role in immunomodulation, hemostasis and inflammation in a wide variety of pathologically altered brain tissues. We have now analyzed expression of COX-1 and COX-2 in brains of patients with CM by immunohistochemistry. Double labeling experiments were used to verify the cellular identity of COX-1 and COX-2 expressing cells. Compared to healthy controls, significant (P=0.0006) accumulation of COX-1 expressing macrophages/microglial cells was detected in Durck's granulomas. Accumulations of COX-2 expressing endothelial cells (P=0.0006) and COX-2 expressing astrocytes (P=0.0012) were detected in CM brain parenchyma. The restricted expression and accumulation of COX-1 and COX-2 in CM brains adds convincing evidence for the participation of cyclooxygenases in the formation of fever, inflammation and granuloma in these patients.
机译：血管内隔离和细胞因子表达模式的改变是决定脑部疟疾（CM）患者中枢神经系统病变形成的关键决定因素。其中，通过临床试验发现CM患者外周血中前列腺素浓度改变。前列腺素的合成受环加氧酶（COX，前列腺素内过氧化物合酶，PGG / H合酶）控制，并且COX的表达被认为在多种病理改变的脑组织中的免疫调节，止血和炎症中起着关键作用。现在，我们已经通过免疫组织化学分析了CM患者大脑中COX-1和COX-2的表达。双重标记实验用于验证COX-1和COX-2表达细胞的细胞身份。与健康对照组相比，在Durck肉芽肿中检测到大量表达COX-1的巨噬细胞/小胶质细胞积聚（P = 0.0006）。在CM脑实质中检测到表达COX-2的内皮细胞（P = 0.0006）和表达COX-2的星形胶质细胞（P = 0.0012）的积累。 CM大脑中COX-1和COX-2的表达和积累受到限制，为这些患者中加氧酶参与发烧，发炎和肉芽肿形成提供了令人信服的证据。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号