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首页> 外文期刊>Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology >Behavioral characterization of a mouse model of premature immunosenescence.
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Behavioral characterization of a mouse model of premature immunosenescence.

机译：行为模型的小鼠过早免疫衰老。

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In previous studies we have shown that differences in life span among members of Swiss mouse populations appear to be related to their performance in a T-maze, with a slow performance ("slow" mice) being linked to an impaired immune function and a shorter life span when compared to "fast" mice, which led us to propose the slow mice as a model of immunosenescence. In the present study we demonstrate that in a tightrope test of neuromuscular vigor and coordination the slow mice show a worse performance, needing more time to complete the task. Moreover, these animals show a decreased locomotor activity and an increased level of emotionality/anxiety in three standard behavioral tests (the holeboard, the open field and the plus-maze) when compared to fast mice. All these behavioral features were most marked in the slow females. The results also indicate that slow animals show a decreased chemotaxis of macrophages and lymphocytes, as well as a reduced lymphoproliferative response to mitogens. The data supports our claim that slow or hyperemotional mice, in which immune and neurobehavioural functions appear to be impaired, may be a useful model of premature aging.
机译：在先前的研究中，我们表明，瑞士小鼠种群成员之间寿命的差异似乎与它们在T型迷宫中的表现有关，其中缓慢的表现（“缓慢”的小鼠）与免疫功能受损和时间较短有关。与“快”小鼠相比，其寿命更长，这使我们提出了慢小鼠作为免疫衰老的模型。在本研究中，我们证明了在对神经肌肉活力和协调性的绳索测试中，慢速小鼠表现出较差的表现，需要更多时间才能完成任务。此外，与快速小鼠相比，这些动物在三种标准的行为测试（洞洞板，开阔的视野和迷宫）中表现出运动能力降低和情绪/焦虑水平提高。所有这些行为特征在缓慢的女性中最为明显。结果还表明，慢速动物的巨噬细胞和淋巴细胞趋化性降低，对促分裂原的淋巴细胞增生反应降低。数据支持了我们的观点，即免疫力和神经行为功能受损的慢速或高情绪小鼠可能是早衰的有用模型。

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