Genetic linkage analysis of the antibody responses to myelin basic protein and myelin oligodendrocyte glycoprotein in rats immunized with rat spinal cord homogenate.

Yang HT; Bergsteinsdottir K; Wernhoff P; Linington C; Pettersson U; Holmdahl R

首页> 外文期刊>Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology >Genetic linkage analysis of the antibody responses to myelin basic protein and myelin oligodendrocyte glycoprotein in rats immunized with rat spinal cord homogenate.

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Genetic linkage analysis of the antibody responses to myelin basic protein and myelin oligodendrocyte glycoprotein in rats immunized with rat spinal cord homogenate.

机译：用脊髓匀浆免疫的大鼠对髓鞘碱性蛋白和髓鞘少突胶质细胞糖蛋白抗体反应的遗传连锁分析。

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The genetic control of the antibody response to myelin basic protein (MBP) and myelin oligodendrocyte glycoprotein (MOG) was analysed in F1 and F2 crosses of DA and E3 rats, immunized with rat spinal chord homogenate. The DA rats were highly susceptible to encephalomyelitis and made antibody responses to both MBP and MOG, whereas the E3 rats were disease-resistant and responded only to MOG. The anti-MBP response was mainly controlled by the disease-promoting MHC region of the DA strain together with several disease loci outside MHC. In contrast, the anti-MOG response was associated with loci not related to or actually conferring resistance to disease.

机译：在用大鼠脊髓匀浆免疫的DA和E3大鼠的F1和F2杂交中，分析了对髓鞘碱性蛋白（MBP）和髓鞘少突胶质细胞糖蛋白（MOG）的抗体应答的遗传控制。 DA大鼠极易患脑脊髓炎，并对MBP和MOG均产生抗体应答，而E3大鼠具有抗病性，仅对MOG应答。抗MBP反应主要由DA菌株的促进疾病的MHC区域以及MHC外部的几个疾病位点控制。相反，抗MOG应答与与疾病无关或实际上赋予抗病性的基因座相关。

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《Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology》 |2001年第2期|共9页
作者
Yang HT; Bergsteinsdottir K; Wernhoff P; Linington C; Pettersson U; Holmdahl R;
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正文语种 eng
中图分类神经病学与精神病学;医学免疫学;
关键词
Linkage Genetics; Myelin Basic Proteins; Myelin-Associated Glycoprotein; 髓磷脂碱性蛋白质类; 髓磷脂相关糖蛋白; 脊髓;

机译：Linkage Genetics;Myelin Basic Proteins;Myelin-Associated Glycoprotein;髓磷脂碱性蛋白质类;髓磷脂相关糖蛋白;脊髓;

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1. Genetic linkage analysis of the antibody responses to myelin basic protein and myelin oligodendrocyte glycoprotein in rats immunized with rat spinal cord homogenate. [J] . Yang HT, Bergsteinsdottir K, Wernhoff P, Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology . 2001,第1a2期

机译：用脊髓匀浆免疫的大鼠对髓鞘碱性蛋白和髓鞘少突胶质细胞糖蛋白抗体反应的遗传连锁分析。
2. Antibody response to myelin oligodendrocyte glycoprotein and myelin basic protein depend on familial background and are partially associated with human leukocyte antigen alleles in multiplex families and sporadic multiple sclerosis. [J] . Lutterotti A, Reindl M, Gassner C, Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology . 2002,第1a2期

机译：对髓鞘少突胶质细胞糖蛋白和髓鞘碱性蛋白的抗体应答取决于家族背景，并且与多重家族和偶发性多发性硬化中的人白细胞抗原等位基因部分相关。
3. Antibodies against the myelin oligodendrocyte glycoprotein and the myelin basic protein in multiple sclerosis and other neurological diseases: a comparative study. [J] . Reindl M, Linington C, Brehm U, Brain: A journal of neurology . 1999,第Pta11期

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4. T cell receptor altered peptide ligands of Myelin Basic Protein and Proteolipid Protein (Linear and Cyclic) can modulate immune responses in SJL/J mice: Bioactive peptides for Multiple Sclerosis [C] . Maria Katsara, Theodore Tselios, Spyros Deraos International Peptide Symposium . 2009

机译：T细胞受体改变髓鞘碱性蛋白质和蛋白质（线性和环状）的肽配体可以调节SJL / J小鼠中的免疫应答：用于多发性硬化的生物活性肽
5. T cell expression of MHC class II glycoproteins: Presentation of the self-peptide rat myelin basic protein induces tolerance in the Lewis rat model of EAE. [D] . Walker, Mindi Renee. 2002

机译：MHC II类糖蛋白的T细胞表达：在EAE的Lewis大鼠模型中，自肽大鼠髓磷脂碱性蛋白的存在诱导了耐受性。
6. Temporospatial Expression and Cellular Localization of Oligodendrocyte Myelin Glycoprotein (OMgp) after Traumatic Spinal Cord Injury in Adult Rats [O] . Fangfang Dou, Lidong Huang, Panpan Yu, -1

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机译：髓鞘寡核腺细胞糖蛋白 - 抗体（MOG-IgG）相关疾病，在14个月的儿童中位于中央脊髓病变
8. Light and Electron Microscopic Alterations in Spinal Cord Myelin Sheaths after Decompression Sickness [R] . Sykes, J. J., Yaffe, L. J. 1985

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Genetic linkage analysis of the antibody responses to myelin basic protein and myelin oligodendrocyte glycoprotein in rats immunized with rat spinal cord homogenate.

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