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首页> 外文期刊>Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology >Sex differences in cytokine responses to myelin peptides in multiple sclerosis.
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Sex differences in cytokine responses to myelin peptides in multiple sclerosis.

机译：多发性硬化症中细胞因子对髓磷脂肽的反应中的性别差异。

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摘要

Many autoimmune diseases preferentially affect women; however, the underlying mechanisms for the sex differences are poorly understood. We examined sex-dependent differences in the immunologic response to myelin proteins in 22 multiple sclerosis (MS) patients and 22 healthy controls. Using ELISA spot assay (ELISPOT) methodology, interferon (IFN) gamma and IL-5 secretions were examined at the single cell level in response to overlapping proteolipid protein (PLP) peptides. As previously reported, we observed an overall disease effect in the IFNgamma response, such that MS patients were significantly higher than controls. With respect to PLP-induced IFNgamma secretion, both MS and control females responded higher than their corresponding males. Female MS patients demonstrated the highest responses compared to MS males or healthy controls of either sex. Although MS females had high IFNgamma responses to PLP, they had no IL-5 responses at all, suggesting strong Th1 skewing. In contrast, MS males had more IL-5 than control males, who lacked IL-5 responses. These IL-5 responses suggested that disease and gender are not independent, but rather interact to influence the cytokine response to myelin. The data suggest a gender bias towards Th1 responses in MS, which may contribute to the female predominance in this disease.
机译：许多自身免疫性疾病优先影响妇女;然而，对于性别差异的潜在机制了解甚少。我们检查了22位多发性硬化症（MS）患者和22位健康对照者对髓磷脂蛋白的免疫应答中的性别依赖性差异。使用ELISA斑点测定（ELISPOT）方法，响应于重叠的脂蛋白（PLP）肽，在单个细胞水平上检查了干扰素（IFN）γ和IL-5分泌。如先前报道的，我们观察到了IFNγ反应的总体疾病影响，因此MS患者明显高于对照组。关于PLP诱导的IFNγ分泌，MS和对照雌性的反应均高于其相应的雄性。与MS男性或任何性别的健康对照相比，女性MS患者表现出最高的反应。尽管MS女性对PLP的IFNgamma应答较高，但她们根本没有IL-5应答，表明Th1偏斜很强。相比之下，MS男性的IL-5多于缺乏IL-5反应的对照男性。这些IL-5应答表明疾病和性别不是独立的，而是相互作用以影响细胞因子对髓磷脂的应答。数据表明，MS患者对Th1反应存在性别偏见，这可能导致女性在该疾病中占主导地位。

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