Borrelia burgdorferi induces inflammatory mediator production by murine microglia.

Rasley A; Anguita J; Marriott I

首页> 外文期刊>Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology >Borrelia burgdorferi induces inflammatory mediator production by murine microglia.

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Borrelia burgdorferi induces inflammatory mediator production by murine microglia.

机译：伯氏疏螺旋体诱导鼠小胶质细胞产生炎症介质。

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Lyme disease has been associated with damaging inflammation within the central nervous system. In the present study, we demonstrate that Borrelia burgdorferi is a significant stimulus for the production of IL-6, TNF-alpha, and PGE(2) by microglia. This effect is associated with induction of NF-kappaB, and increased expression of Toll-like receptor 2 and CD14, receptors known to underlie spirochete activation of other immune cell types. These studies identify microglia as a previously unappreciated source of inflammatory mediator production following challenge with B. burgdorferi. Such production may play an important role during the development of Lyme neuroborreliosis.

机译：莱姆病已与中枢神经系统的破坏性炎症相关。在本研究中，我们证明了伯氏疏螺旋体是小胶质细胞产生IL-6，TNF-α和PGE（2）的重要刺激。这种作用与NF-κB的诱导以及Toll样受体2和CD14的表达增加有关，Toll样受体2和CD14已知是其他免疫细胞类型的螺旋体激活的基础。这些研究将小胶质细胞鉴定为对B. burgdorferi的攻击后，炎症介质产生的先前未被认识的来源。此类产生可能在莱姆神经疏螺旋体的发展过程中起重要作用。

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《Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology》 |2002年第2期|共1页
作者
Rasley A; Anguita J; Marriott I;
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正文语种 eng
中图分类神经病学与精神病学;医学免疫学;
关键词
Production; Microglia; Borrelia burgdorferi; Toll-like receptor; 小神经胶质细胞; 疏螺旋体; 伯氏;

机译：Production;Microglia;Borrelia burgdorferi;Toll-like receptor;小神经胶质细胞;疏螺旋体;伯氏;

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1. Borrelia burgdorferi induces inflammatory mediator production by murine microglia. [J] . Rasley A, Anguita J, Marriott I Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology . 2002,第1a2期

机译：伯氏疏螺旋体诱导鼠小胶质细胞产生炎症介质。
2. Borrelia burgdorferi BBB07 interaction with integrin alpha(3)beta(1) stimulates production of pro-inflammatory mediators in primary human chondrocytes [J] . Behera AK, Durand E, Cugini C, Cellular microbiology . 2008,第2期

机译：伯氏疏螺旋体BBB07与整合素α（3）β（1）的相互作用刺激原代人类软骨细胞中促炎性介质的产生
3. ce:italic>Borrelia burgdorferi/ce:italic> basic membrane protein A could induce chemokine production in murine microglia cell line BV2 [J] . Hua Zhao, Aihua Liu, Yuhui Cui, Microbial Pathogenesis . 2017,第期

机译：＆ ce：斜体> borrelia burgdorferi＆ / ce：斜体>碱性膜蛋白A可以诱导鼠髓细胞系BV2中的趋化因子生产
4. INDOOR AIR BACTERIA INDUCE MORE INTENSE PRODUCTION OF INFLAMMATORY MEDIATORS THAN FUNGAL SPORES IN MOUSE AND HUMAN MACROPHAGES [C] . K Huttunen, A Hyvaerinen, A Nevalainen, International conference on indoor air quality and climate . 2002

机译：室内空气细菌诱导比小鼠和人类巨噬细胞的真菌孢子更强烈地产生炎症介质
5. Didox modulates reactive oxygen species production and inflammatory events induced by lipopolysaccharide (LPS) and aryl hydrocarbon receptor (AHR) ligands in raw 264.7 murine macrophages. [D] . Matsebatlela, Thabe Moses. 2009

机译：Didox调节未加工的264.7鼠巨噬细胞中脂多糖（LPS）和芳烃受体（AHR）配体引起的活性氧的产生和炎症事件。
6. Borrelia burgdorferi Elicited-IL-10 Suppresses the Production of Inflammatory Mediators Phagocytosis and Expression of Co-Stimulatory Receptors by Murine Macrophages and/or Dendritic Cells [O] . Yutein Chung, Nan Zhang, R. Mark Wooten -1

机译：伯氏疏螺旋体-IL-10抑制了炎症调节剂的产生吞噬作用以及鼠巨噬细胞和/或树突状细胞共刺激受体的表达。
7. Borrelia burgdorferi elicited-IL-10 suppresses the production of inflammatory mediators, phagocytosis, and expression of co-stimulatory receptors by murine macrophages and/or dendritic cells. [O] . Yutein Chung, Nan Zhang, R Mark Wooten 2013

机译：伯氏疏螺旋体引发的IL-10抑制小鼠巨噬细胞和/或树突细胞的炎症介质的产生，吞噬作用和共刺激受体的表达。

Borrelia burgdorferi induces inflammatory mediator production by murine microglia.

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