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首页> 外文期刊>Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology >Haemophilus influenzae as a possible cause of Guillain-Barre syndrome.
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Haemophilus influenzae as a possible cause of Guillain-Barre syndrome.

机译：流感嗜血杆菌可能是格林-巴利综合征的可能原因。

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摘要

Recent reports have contained conflicting results on the relationship between antecedent Haemophilus influenzae infection and Guillain-Barre syndrome (GBS). To investigate the prevalence of H. influenzae infection in GBS patients in a British population, we carried out a retrospective study with 62 consecutive GBS patients and 63 normal controls of similar age and sex. Whole bacteria of both encapsulated and nonencapsulated strains of H. influenzae were employed as antigens in an enzyme-linked immunosorbent assay (ELISA) for anti-H. influenzae IgG, IgM and IgA antibodies. Elevated antibodies of two or three classes were found in one GBS patient and none in the normal controls. Six GBS patients had IgG antibodies against nonencapsulated H. influenzae compared with only one in the normal control group (p=0.06). Western blot for IgG antibody showed that all the sera with IgG antibodies recognized the lipopolysaccharide (LPS) of both strains of H. influenzae. Antiganglioside GM1 antibody was not associatedwith anti-H. influenzae antibody in our study. Absorption with encapsulated or nonencapsulated H. influenzae, Campylobacter jejuni and Escherichia coli before testing on Western blot showed that only nonencapsulated H. influenzae absorbed the anti-LPS antibodies. In conclusion, there is a possible but rare association of GBS with nonencapsulated H. influenzae in the UK.
机译：最近的报道对先前的流感嗜血杆菌感染与格林-巴利综合症（GBS）之间的关系存在矛盾的结果。为了调查英国人群GBS患者中流感嗜血杆菌的感染率，我们对62例连续的GBS患者和63名年龄和性别相仿的正常对照进行了回顾性研究。在抗H的酶联免疫吸附测定（ELISA）中，将流感嗜血杆菌的封装和非封装菌株的完整细菌用作抗原。流感IgG，IgM和IgA抗体。在一名GBS患者中发现了两到三类抗体升高，而在正常对照中则没有。 6名GBS患者具有针对未封装的流感嗜血杆菌的IgG抗体，而正常对照组中只有1名（p = 0.06）。 IgG抗体的蛋白质印迹显示，所有带有IgG抗体的血清均能识别两种流感嗜血杆菌菌株的脂多糖（LPS）。抗神经节苷脂GM1抗体与抗H无关。我们研究中的流感抗体。在Western印迹测试之前，用封装的或未封装的流感嗜血杆菌，空肠弯曲杆菌和大肠杆菌进行吸收显示，只有未封装的流感嗜血杆菌吸收了抗LPS抗体。总之，在英国，GBS与未封装的流感嗜血杆菌可能存在但罕见的关联。

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