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首页> 外文期刊>Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology >Proximity between 5-HT secreting enteroendocrine cells and lymphocytes in the gut mucosa of rhesus macaques (Macaca mulatta) is suggestive of a role for enterochromaffin cell 5-HT in mucosal immunity.
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Proximity between 5-HT secreting enteroendocrine cells and lymphocytes in the gut mucosa of rhesus macaques (Macaca mulatta) is suggestive of a role for enterochromaffin cell 5-HT in mucosal immunity.

机译：恒河猴（Macaca mulatta）的肠道粘膜中分泌5-HT的肠内分泌细胞与淋巴细胞之间的邻近性提示肠嗜铬细胞5-HT在粘膜免疫中的作用。

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摘要

The involvement of serotonin (5-hydroxytryptamine; 5-HT) in immunoregulation has been well documented. Gut mucosa is a large reservoir of 5-HT most of which is attributed to gut endocrine cells. In this study, we examined the anatomical relationship among 5-HT immunoreactive cells and T and B lymphocytes in the gut mucosa of rhesus monkeys (Macaca mulatta). 5-HT, CD3 and CD20 immunoreactive cells were immunofluorescently labeled and visualized by confocal microscopy. 5-HT immunoreactive cells were primarily found within the epithelium of the intestine and were present at all levels of the gastrointestinal tract. Many 5-HT immunoreactive cells were in contact with, or very close proximity to CD3(+) and CD20(+) lymphocytes. These results provide morphological evidence to suggest interactions between 5-HT secreting enteroendocrine cells and lymphocytes in the gut mucosa. This further supports a possible role of 5-HT in mucosal immune responses.
机译：5-羟色胺（5-羟色胺; 5-HT）参与免疫调节已被充分证明。肠粘膜是5-HT的大量储库，其中大部分归因于肠道内分泌细胞。在这项研究中，我们检查了猕猴肠道黏膜中5-HT免疫反应性细胞与T和B淋巴细胞之间的解剖关系。对5-HT，CD3和CD20免疫反应性细胞进行免疫荧光标记，并通过共聚焦显微镜观察。 5-HT免疫反应性细胞主要存在于肠上皮中，并存在于胃肠道的所有水平。许多5-HT免疫反应性细胞与CD3（+）和CD20（+）淋巴细胞接触或非常接近。这些结果提供了形态学证据，表明肠粘膜中分泌5-HT的肠内分泌细胞与淋巴细胞之间存在相互作用。这进一步支持了5-HT在粘膜免疫应答中的可能作用。

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