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首页> 外文期刊>Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology >Cytokine profile in patients with multiple sclerosis following vitamin D supplementation.
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Cytokine profile in patients with multiple sclerosis following vitamin D supplementation.

机译：补充维生素D后多发性硬化患者的细胞因子谱。

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摘要

Multiple sclerosis (MS) patients were randomized, in a double blind design, and placed into either a vitamin D supplemented group or a placebo control group. As expected, serum 25-hydroxyvitamin D levels increased significantly following 6 month vitamin D supplementation (17+/-6 ng/ml at baseline to 28+/-8 ng/ml at 6 months). Vitamin D supplementation also significantly increased serum transforming growth factor (TGF)-beta1 levels from 230+/-21 pg/ml at baseline to 295+/-40 pg/ml 6 months later. Placebo treatment had no effect on serum TGF-beta1 levels. Tumor necrosis factor (TNF)-alpha, interferon (IFN)-gamma, and interleukin (IL)-13 were not different following vitamin D supplementation. IL-2 mRNA levels decreased following vitamin D supplementation but the differences did not reach significance. Vitamin D supplementation of MS patients for 6 months was associated with increased vitamin D status and serum TGF-beta1.
机译：采用双盲设计将多发性硬化症（MS）患者随机分组，并置于补充维生素D的组或安慰剂对照组中。如预期的那样，补充维生素D六个月后，血清25-羟基维生素D水平显着增加（基线时为17 +/- 6 ng / ml，六个月时为28 +/- 8 ng / ml）。补充维生素D还可以将血清转化生长因子（TGF）-beta1水平从基线时的230 +/- 21 pg / ml显着提高到6个月后的295 +/- 40 pg / ml。安慰剂治疗对血清TGF-β1水平无影响。补充维生素D后，肿瘤坏死因子（TNF）-α，干扰素（IFN）-γ和白介素（IL）-13相同。补充维生素D后IL-2 mRNA水平下降，但差异未达到显着水平。 MS患者补充6个月的维生素D与增加维生素D状态和血清TGF-beta1有关。

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