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首页> 外文期刊>Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology >Autoantibodies to peripheral nerve glycosphingolipids SPG, SLPG, and SGPG in Guillain-Barre syndrome and chronic inflammatory demyelinating polyneuropathy.
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Autoantibodies to peripheral nerve glycosphingolipids SPG, SLPG, and SGPG in Guillain-Barre syndrome and chronic inflammatory demyelinating polyneuropathy.

机译：在格林-巴利综合征和慢性炎症性脱髓鞘性多发性神经病中针对外周神经糖鞘脂SPG，SLPG和SGPG的自身抗体。

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Unlike CNS myelin, human peripheral nerve myelin has the acidic glycosphingolipids sialosyl paragloboside (SPG), sialosyl lactosaminyl paragloboside (SLPG), and sulfated glucuronyl paragloboside (SGPG). To elucidate the pathogenesis of Guillain-Barre syndrome (GBS) and chronic inflammatory demyelinating neuropathy (CIDP), we investigated the autoantibodies to peripheral nerve molecules in patients with these diseases and compared the frequency of the autoantibodies with that of autoantibody to GM1 which is present in both the CNS and PNS. The report of Sheikh et al. (Ann. Neurol. 1995; 38: 350) that Campylobacter jejuni bears the SGPG epitope led us to study whether sera from patients with GBS subsequent to C. jejuni enteritis have anti-SGPG antibody; but, high anti-SGPG antibody titers were not found in the GBS patients from whom C. jejuni was isolated. Although the frequency of the anti-SPG, anti-SLPG and anti-SGPG antibodies were lower than that of the anti-GM1 antibody in GBS, 5 patients with demyelinating GBS had high IgG anti-SPG antibody titers. IgG anti-SPG antibody may function in the development of demyelinating GBS. We found that 6 CIDP patients had elevated IgM anti-SGPG antibody titers. Immunoelectrophoresis failed to detect IgM M-protein in 3 of the patients. IgM anti-SGPG antibody could be a diagnostic marker for a subgroup of CIDP with or without paraprotein.
机译：与中枢神经系统髓磷脂不同，人周围神经髓磷脂具有酸性糖鞘脂唾液酸副糖苷（SPG），唾液酸乳糖胺基副糖苷（SLPG）和硫酸化葡糖醛酸糖副糖苷（SGPG）。为了阐明格林-巴利综合征（GBS）和慢性炎症性脱髓鞘性神经病（CIDP）的发病机理，我们研究了这些疾病患者外周神经分子的自身抗体，并将自身抗体与自身抗体与GM1的频率进行了比较在CNS和PNS中都是如此。谢赫等人的报告。 （Ann。Neurol。1995; 38：350）空肠弯曲杆菌携带SGPG表位，导致我们研究空肠弯曲杆菌肠炎后GBS患者血清是否具有抗SGPG抗体。但是，在分离空肠弯曲杆菌的GBS患者中未发现高抗SGPG抗体滴度。尽管在GBS中抗SPG，抗SLPG和抗SGPG抗体的频率低于抗GM1抗体，但5名脱髓鞘性GBS的患者具有较高的IgG抗SPG抗体滴度。 IgG抗SPG抗体可能在脱髓鞘性GBS的发展中起作用。我们发现6名CIDP患者的IgM抗SGPG抗体滴度升高。免疫电泳未能在3例患者中检测到IgM M蛋白。 IgM抗SGPG抗体可能是有或没有副蛋白的CIDP亚组的诊断标记。

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