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首页> 外文期刊>Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology >Chronic electric stimulation of the midbrain ventral tegmental area increases spleen but not blood natural killer cell cytotoxicity in rats.
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Chronic electric stimulation of the midbrain ventral tegmental area increases spleen but not blood natural killer cell cytotoxicity in rats.

机译：慢性电刺激中脑腹侧被盖区可增加大鼠脾脏，但不会增加血液中自然杀伤细胞的细胞毒性。

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Previously we found that in conscious, freely behaving rats chronic electric stimulation of the lateral hypothalamus (LH) caused significant augmentation of natural killer cell cytotoxicity (NKCC) and a large granular lymphocyte (LGL) number more pronounced in the spleen than in the peripheral blood. The LH belongs to the so-called "brain reward system", a collection of the central structures whose activation produce positive emotions. The midbrain ventral tegmental area (VTA) is another prominent reward-relevant structure. In the present work, chronic electric stimulation of VTA (constant current 0.1 ms duration cathodal pulses delivered at frequency 50 Hz during 60 min daily session for 14 consecutive days) caused in rats an increase in the spleen but not in the peripheral blood NKCC (chromium release assay) without simultaneous effect on the number of large granular lymphocytes (LGL) (morphological method) and plasma level of prolactin (PRL), growth hormone (GH), corticosterone (COR), and testosterone (TST). This effect was anatomically specific as no influence of analogous thalamic stimulation on immune and endocrine response was found. The results obtained indicate that both reward-related areas VTA and LH enhance the cell-mediated immune response, represented by natural killer cytotoxicity, especially in the spleen. However, the effect pronounced by VTA is weaker than that of LH, possibly due to additional connections of LH with the hormonal and/or autonomic control systems.
机译：先前，我们发现在行为自觉的大鼠中，长期电刺激下丘脑外侧（LH）导致自然杀伤细胞的细胞毒性（NKCC）显着增加，并且脾脏中的大颗粒淋巴细胞（LGL）数量比外周血更明显。 LH属于所谓的“大脑奖励系统”，是中央结构的集合，其激活会产生积极的情绪。中脑腹侧被盖区（VTA）是另一个重要的奖赏相关结构。在当前的工作中，VTA的慢性电刺激（在连续60天的每天60分钟内，在每天60分钟的频率下以50 Hz的频率持续施加持续时间为0.1 ms的阴极脉冲，连续14天）导致大鼠脾脏增加，但外周血NKCC却没有增加（铬释放测定法）对大颗粒淋巴细胞（LGL）的数量（形态学方法）和催乳素（PRL），生长激素（GH），皮质酮（COR）和睾丸激素（TST）的血浆水平没有同时影响。由于没有发现类似丘脑刺激对免疫和内分泌反应的影响，因此这种作用在解剖上是特异性的。获得的结果表明，与报酬相关的区域VTA和LH均增强了细胞介导的免疫反应，表现为自然杀伤性细胞毒性，特别是在脾脏中。但是，VTA的效果比LH弱，这可能是由于LH与激素和/或自主控制系统的其他连接所致。

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