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首页> 外文期刊>Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology >Experimental autoimmune neuritis induces differential microglia activation in the rat spinal cord.
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Experimental autoimmune neuritis induces differential microglia activation in the rat spinal cord.

机译：实验性自身免疫性神经炎在大鼠脊髓中诱导差异性小胶质细胞活化。

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摘要

The reactive spatial and temporal activation pattern of parenchymal spinal cord microglia was analyzed in rat experimental autoimmune neuritis (EAN). We observed a differential activation of spinal cord microglial cells. A significant increase in ED1(+) microglia predominantly located in the dorsal horn grey matter of lumbar and thoracic spinal cord levels was observed on Day 12. As revealed by morphological criteria and by staining with further activation markers [allograft inflammatory factor 1 (AIF-1), EMAPII, OX6, P2X(4)R], reactive microglia did not reach a macrophage-like state of full activation. On Day 12, a significant proliferative response could be observed, affecting all spinal cord areas and including ED1(+) microglial cells and a wide range of putative progenitor cells. Thus, in rat EAN, a reactive localized and distinct microglial activation correlating with a generalized proliferative response could be observed.
机译：在大鼠实验性自身免疫性神经炎（EAN）中分析了实质性脊髓小胶质细胞的反应性时空激活模式。我们观察到脊髓小胶质细胞的差异激活。在第12天观察到ED1（+）小胶质细胞显着增加，主要位于腰椎和胸部脊髓水平的背角灰质中。 1），EMAPII，OX6，P2X（4）R]，反应性小胶质细胞未达到完全激活的巨噬细胞样状态。在第12天，可以观察到明显的增殖反应，影响所有脊髓区域，包括ED1（+）小胶质细胞和广泛的推定祖细胞。因此，在大鼠EAN中，可以观察到与普遍的增殖反应相关的反应性局部和独特的小胶质细胞活化。

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