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首页> 外文期刊>Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology >Cerebrospinal fluid interferon-gamma-inducible protein 10 (IP-10, CXCL10) in HIV-1 infection.
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Cerebrospinal fluid interferon-gamma-inducible protein 10 (IP-10, CXCL10) in HIV-1 infection.

机译：HIV-1感染中的脑脊液干扰素-γ诱导蛋白10（IP-10，CXCL10）。

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Interferon-gamma-inducible protein (IP-10 or CXCL10) is a potent chemoattractant and has been suggested to enhance retrovirus infection and mediate neuronal injury. In order to assess this chemokine in central nervous system (CNS) HIV infection, we measured the cerebrospinal fluid (CSF) and plasma concentrations of CXCL10 by immunoassay in samples derived from 97 HIV-infected subjects across a spectrum of immunological progression and CNS complications and from 16 HIV seronegative control subjects studied at three clinical centers between 1994 and 2001. We also examined changes in the CSF and plasma CXCL10 concentrations in 30 subjects starting and three stopping antiretroviral therapy. CSF CXCL10 concentrations: (1) correlated with CSF HIV RNA and white blood cell (WBC) counts, but not with blood CXCL10, HIV RNA, or CD4 counts; (2) were increased in subjects with primary and asymptomatic HIV infections and AIDS dementia complex, but less frequently in those with more advanced infection, with or without CNS opportunistic diseases except cytomegalovirus encephalitis; (3) decreased in subjects starting antiretroviral in association with decreases in CSF and plasma HIV RNA and CSF WBCs; and (4) conversely, increased in subjects stopping treatment in parallel with CSF HIV RNA and WBCs. These results confirm that CSF CXCL10 associates closely with both CSF HIV and WBCs and suggest that this chemokine may be both a response to and contributing determinant of local infection. High CSF levels may be useful in the diagnosis of ADC in subjects with advanced immunosuppression in whom CMV encephalitis has been ruled out, though this issue requires further study.
机译：干扰素-γ诱导蛋白（IP-10或CXCL10）是一种强大的化学引诱剂，已被认为可增强逆转录病毒感染并介导神经元损伤。为了评估这种趋化因子在中枢神经系统（CNS）HIV感染中的作用，我们通过免疫测定法对来自97名HIV感染者的样品进行了一系列免疫学测定，中枢神经系统并发症和我们从1994年至2001年在三个临床中心对16名HIV血清阴性对照受试者进行了研究。我们还检查了30名开始和终止抗逆转录病毒治疗的受试者中CSF​​和血浆CXCL10浓度的变化。 CSF CXCL10浓度：（1）与CSF HIV RNA和白细胞（WBC）计数相关，但与血液CXCL10，HIV RNA或CD4计数无关; （2）在患有原发性和无症状HIV感染和AIDS痴呆症的受试者中有所增加，而在晚期感染中有或没有CNS机会性疾病的巨细胞病毒性脑炎除外的人群中发病率降低; （3）与抗CSF和血浆HIV RNA和CSF白细胞减少有关的开始抗逆转录病毒治疗的受试者减少; （4）相反地，与CSF HIV RNA和WBC并行停止治疗的受试者增加。这些结果证实，CSF CXCL10与CSF HIV和WBC密切相关，并表明该趋化因子既可能是对局部感染的反应，又是其决定因素。对于已被排除CMV脑炎的晚期免疫抑制患者，高CSF水平可能有助于诊断ADC，尽管这个问题需要进一步研究。

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