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首页> 外文期刊>Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology >Programmed cell death of myelin basic protein-specific T lymphocytes is reduced in patients with acute multiple sclerosis.
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Programmed cell death of myelin basic protein-specific T lymphocytes is reduced in patients with acute multiple sclerosis.

机译：急性多发性硬化症患者的髓磷脂碱性蛋白特异性T淋巴细胞程序性细胞死亡减少。

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摘要

We investigated the apoptosis of myelin basic protein (MBP)-specific T lymphocytes in multiple sclerosis (MS) patients with acute (AMS) or stable (SMS) MS by evaluating the expression of apoptosis markers on peripheral cells. Cells of healthy controls (HC) were evaluated as well. Results showed that mitogen-stimulated apoptosis was comparable among patients and controls, whereas MBP-stimulated CD4+ and CD8+ 7-AAD+ and 7-AAD+ Fas+ cell (apoptotic cells) were significantly reduced in AMS patients. A reduction of the apoptotic rate of myelin-specific CD4+ and CD8+ T lymphocytes could be involved in the immune-mediated destruction of the myelin sheath seen in AMS patients.
机译：我们通过评估周围细胞凋亡标记物的表达，研究了多发性硬化症（MS）急性（AMS）或稳定（SMS）MS患者中髓鞘碱性蛋白（MBP）特异性T淋巴细胞的凋亡。还评估了健康对照（HC）的细胞。结果显示，有丝分裂原刺激的细胞凋亡在患者和对照组之间相当，而在AMS患者中，MBP刺激的CD4 +和CD8 + 7-AAD +和7-AAD + Fas +细胞（凋亡细胞）显着减少。髓鞘特异性CD4 +和CD8 + T淋巴细胞凋亡率的降低可能与AMS患者所见的髓鞘的免疫介导破坏有关。

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