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首页> 外文期刊>Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology >Noradrenaline transporter and its turnover rate are decreased in blood lymphocytes of patients with major depression.
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Noradrenaline transporter and its turnover rate are decreased in blood lymphocytes of patients with major depression.

机译：抑郁症患者血液中的去甲肾上腺素转运蛋白及其更新率降低。

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Lymphocytes possess transporters of serotonin and dopamine, and also contain monoamines. The objective of this work was to determine the presence of noradrenaline transporters, the turnover rate of noradrenaline and serotonin in lymphocytes of major depression patients, and to correlate the biochemical parameters with the severity of the disorder. Lymphocytes from peripheral blood were isolated by Ficoll/Hypaque, and noradrenaline transporter was studied by binding of [3H]nisoxetine: control group (29, age 31.52+/-1.08, 7 men) and major depression patients (35, age 36.68+/-1.69, 6 men), Hospital Vargas de Caracas. Diagnostic was done by criteria of the American Psychiatric Association and severity by Hamilton Scale for Depression. Levels of noradrenaline, serotonin, 3-methoxy-4-hydroxyphenylglycol and 5-hydroxyindoleacetic acid were determined by HPLC. Turnover rate was evaluated by the ratios of monoamines and metabolites. Correlations were done between the biochemical parameters and the severity of depression. The score of Hamilton for Depression was 22.77+/-0.51. There was a reduction in the number of transporters in lymphocytes of patients, 0.95+/-0.27 versus 4.06+/-1.67 fmol/10(6) cells. Levels of monoamines and metabolites did not significantly differ between patients and controls. However, there was a higher monoamine/metabolite ratio in lymphocytes of patients, indicating a reduction of metabolic turnover rate. Also there was a relative greater concentration of noradrenaline than serotonin in the lymphocytes of the patients, as indicated by the ratio noradrenaline/serotonin. Noradrenergic and serotonergic turnover is decreased in blood peripheral lymphocytes of major depression patients; the reduction in noradrenaline transporter could be related to changes in intracellular levels, and these modifications could result in functional changes of the immune system.
机译：淋巴细胞具有5-羟色胺和多巴胺的转运蛋白，并且还含有单胺。这项工作的目的是确定严重抑郁症患者淋巴细胞中去甲肾上腺素转运蛋白的存在，去甲肾上腺素和血清素的转换率，并将生化参数与疾病的严重程度相关联。通过Ficoll / Hypaque从外周血中分离出淋巴细胞，并通过[3H] nisoxetine的结合研究去甲肾上腺素转运蛋白：对照组（29岁，年龄31.52 +/- 1.08，7名男性）和重度抑郁症患者（35岁，年龄36.68 + / -1.69，6名男子），加拉加斯瓦尔加斯医院。根据美国精神病学协会的标准进行诊断，并根据汉密尔顿抑郁量表进行诊断。通过HPLC测定去甲肾上腺素，5-羟色胺，3-甲氧基-4-羟基苯基乙二醇和5-羟基吲哚乙酸的水平。通过单胺和代谢物的比率评估周转率。在生化参数和抑郁严重程度之间进行了相关性。汉密尔顿抑郁症评分为22.77 +/- 0.51。患者淋巴细胞中转运蛋白的数量减少，从0.95 +/- 0.27 fmol / 10（6）细胞减少到0.95 +/- 0.27。患者和对照组之间单胺和代谢物的水平无显着差异。但是，患者淋巴细胞中单胺/代谢物的比率较高，表明代谢转换率降低。患者的淋巴细胞中去甲肾上腺素的浓度也比血清素高，如去甲肾上腺素/血清素的比值所示。重度抑郁症患者外周血淋巴细胞的去甲肾上腺素能和血清素能转换减少;去甲肾上腺素转运蛋白的减少可能与细胞内水平的改变有关，这些修饰可能导致免疫系统功能的改变。

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