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首页> 外文期刊>Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology >Overactivation of LPS-stimulated microglial cells by co-cultured neurons or neuron-conditioned medium.
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Overactivation of LPS-stimulated microglial cells by co-cultured neurons or neuron-conditioned medium.

机译：共培养神经元或神经元条件培养基对LPS刺激的小胶质细胞过度活化。

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摘要

Microglial activation represents a well known aspect of several neuropathological diseases. However, little is known concerning the role of neurons in starting and modulating this process. In the present report, we demonstrate that differentiated, healthy neurons constitutively release in the culture medium substance(s) that are able to induce a state of overactivation in LPS-stimulated microglial cells. The neuronal factors synergize with LPS in stimulating synthesis and release of interleukin-1beta (IL-1beta) and nitric oxide by microglial cells. Prolonged exposure (72 h) to neuron-conditioned media in the presence of LPS induced microglial apoptosis, thus suggesting that neuronal overactivation of stimulated microglia favors their subsequent apoptotic elimination as part of a safety mechanism.
机译：小胶质细胞活化代表了几种神经病理疾病的众所周知的方面。然而，关于神经元在启动和调节这一过程中的作用知之甚少。在本报告中，我们证明了分化的健康神经元在能够诱导LPS刺激的小胶质细胞过度活化状态的培养基质中组成性释放。神经元因子与LPS协同刺激小胶质细胞合成和释放白介素1β（IL-1β）和一氧化氮。在LPS的存在下，长时间暴露于神经元条件培养基（72小时）会诱导小胶质细胞凋亡，因此表明，作为安全机制的一部分，受刺激的小胶质细胞的神经元过度活化有利于其随后的凋亡消除。

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